| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf141 |
| Uniprot No | Q9NUB4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-165aa |
| 氨基酸序列 | MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVLWLGALGLTIQAVFSTTGPALLLLLVSFLTFDLLHRPAGHTLPQRKLLTRGQSQGAGEGPGQQEALLLQMGTVSGQLSLQDALLLLLMGLGPLLRACGMPLTLLGLAFCLHPWA |
| 分子量 | 43.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下提供的文献为根据常见研究模式生成的示例，实际文献可能需要通过专业数据库（如PubMed、Google Scholar）检索确认：
1. **文献名称**：*Functional characterization of the C20orf141 protein as a regulator of mitochondrial membrane dynamics*
**作者**：Zhang L, et al. (2020)
**摘要**：通过重组表达C20orf141蛋白，研究发现其定位于线粒体膜，并通过与OPA1蛋白互作调控线粒体融合，暗示其在神经退行性疾病中的潜在作用。
2. **文献名称**：*C20orf141 interacts with the mTOR signaling pathway and modulates cellular metabolic activity*
**作者**：Wang Y, et al. (2019)
**摘要**：重组人C20orf141蛋白被证明通过结合mTOR复合物1（mTORC1）抑制其活性，影响细胞增殖和自噬，提示其可能作为代谢相关疾病的治疗靶点。
3. **文献名称**：*Structural analysis of human C20orf141 reveals a conserved thioredoxin-like fold and redox activity*
**作者**：Kim S, et al. (2018)
**摘要**：利用X射线晶体学解析重组C20orf141的结构，发现其具有硫氧还蛋白样结构域，体外实验证实其具有抗氧化功能，可能参与细胞氧化应激反应。
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**注意事项**：
1. 上述文献信息为模拟示例，C20orf141（可能已更名，如TMEM**系列或其他）的研究可能较少，建议通过UniProt数据库（ID：Q96HM7）查询最新功能注释。
2. 若需真实文献，可尝试检索别名（如FAM210A）或结合表型关键词（如“线粒体”“癌症”等）。
3. 未发表研究或预印本（如bioRxiv）可能有相关数据，可进一步探索。
**Background of Recombinant Human C20orf141 Protein**
The recombinant human C20orf141 protein is derived from the *C20orf141* gene (Chromosome 20 Open Reading Frame 141), a poorly characterized protein-coding gene located on human chromosome 20. As an "orphan" protein with limited functional annotation, C20orf141 remains understudied, though its conservation across vertebrates suggests potential biological significance. Structurally, it is predicted to be a small cytoplasmic/nuclear protein with unknown enzymatic or signaling motifs.
Current research indicates that *C20orf141* may be ubiquitously expressed in human tissues, with higher mRNA levels observed in the brain, testes, and immune cells, hinting at roles in neurobiology or immune regulation. Some proteomic studies associate it with cellular stress responses or RNA binding, though these findings require experimental validation. Pathologically, *C20orf141* has been tentatively linked to cancer, with altered expression reported in glioblastoma and colorectal carcinoma, possibly influencing cell proliferation.
Recombinant C20orf141 protein, typically produced in *E. coli* or mammalian expression systems, is utilized to investigate its molecular interactions, structural features, and cellular functions. Its recombinant form enables antibody generation, protein interaction studies, and exploration of its role in diseases. Despite progress, the precise biological mechanisms and clinical relevance of C20orf141 remain elusive, necessitating further studies to decode its physiological and pathological contributions.
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