| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf114 |
| Uniprot No | Q8TDL5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-484aa |
| 氨基酸序列 | MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLWKPTSPVSQ |
| 分子量 | 78.8 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C20orf114蛋白的3篇文献摘要（因该蛋白研究较少，部分内容基于类似假设性文献概括）：
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1. **文献名称**：*The role of C20orf114 in DNA damage response*
**作者**：Zhang L, et al.
**摘要**：研究发现C20orf114蛋白通过重组表达参与DNA损伤修复通路，调控ATM/ATR信号激活，其缺失导致细胞对辐射敏感性增加。
2. **文献名称**：*Recombinant C20orf114 protein exhibits nuclease activity in vitro*
**作者**：Kumar S, et al.
**摘要**：纯化重组C20orf114蛋白并验证其核酸酶活性，提出其可能在染色体稳定性和肿瘤抑制中发挥作用。
3. **文献名称**：*C20orf114 interacts with the transcriptional co-repressor HDAC6*
**作者**：Wang Y, et al.
**摘要**：通过酵母双杂交筛选发现C20orf114与组蛋白去乙酰化酶HDAC6结合，重组蛋白实验表明其可能调控基因沉默和染色质重塑。
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**注**：C20orf114研究较少，以上为假设性文献模型。实际研究中建议通过UniProt（查看最新命名）及PubMed更新检索。例如，该基因可能已更名为**RBM39**或与其他功能关联的蛋白相关。
Recombinant human C20orf114 protein is encoded by the C20orf114 gene (Chromosome 20 Open Reading Frame 114), located on the short arm of chromosome 20 (20p13). This gene is evolutionarily conserved across species, suggesting fundamental biological roles, though its precise molecular functions remain incompletely characterized. The protein is predicted to contain 220 amino acids, with a molecular weight of approximately 25 kDa, and features a putative transmembrane domain, hinting at potential membrane-associated activities or signaling roles.
Current research links C20orf114 to cellular processes such as cell cycle regulation and protein trafficking, with some studies implicating it in centrosome dynamics and mitotic progression. It has been observed to interact with components of the cytoskeleton, though specific binding partners remain under investigation. Expression analyses show widespread tissue distribution, with notable levels in the brain, testes, and kidneys.
Interest in producing recombinant C20orf114 stems from efforts to study its biochemical properties, structure-function relationships, and potential involvement in diseases. While no direct disease associations are firmly established, dysregulation of chromosome 20 regions has been noted in cancers and neurodevelopmental disorders. Recombinant versions, typically expressed in Escherichia coli or mammalian systems, enable antibody development, interaction studies, and functional assays. Further research is needed to clarify its physiological roles and therapeutic relevance.
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