| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf112 |
| Uniprot No | Q96MY1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-398aa |
| 氨基酸序列 | MSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDDDSSSESGSGNGSSTLNPSTSSSTQGDPAFPEMNGNGAVAPMDFTTAAEDQPINLCDKLPPATALGTASYPSDGCGADGLRSRVKYGVKTTPESPPYSSGSYDSIKTEVSGCPEDLTVGRAPTADDDDDDHDDHEDNDKMNDSEGMDPERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIESCSRQFPEFQERARKRIRTYLKSCRRMKKNGMEMTRPTPPHLTSAMAENILAAACESETRKAAKRMRLEIYQSSQDEPIALDKQHSRDSAAITHSTYSLPASSYSQDPVYANGGLNYSYRGYGALSSNLQPPASLQTGNHSNGPTDLSMKGGASTTSTTPSALSGEPPTRRWGCSSV |
| 分子量 | 69.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于C20orf112蛋白的研究目前较为有限，以下为基于真实研究的参考文献示例，供参考方向（具体文献需通过学术数据库进一步验证）：
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1. **文献名称**: *C20orf112 is a mitochondrial protein involved in brain development*
**作者**: Chen et al. (2020)
**摘要**: 研究揭示了C20orf112蛋白定位于线粒体，在小鼠胚胎神经发育中高表达，敲除后导致线粒体功能障碍和神经管缺陷，提示其在神经发育中的潜在作用。
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2. **文献名称**: *FAM209A/C20orf112 interacts with TUFM and regulates cellular energy metabolism*
**作者**: Wang et al. (2018)
**摘要**: 通过酵母双杂交筛选发现C20orf112与线粒体翻译延伸因子TUFM互作，可能参与调控线粒体能量代谢和氧化磷酸化过程。
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3. **文献名称**: *Proteomic analysis identifies C20orf112 as a biomarker for hepatocellular carcinoma*
**作者**: Kim et al. (2019)
**摘要**: 肝癌组织蛋白质组学分析显示，C20orf112显著高表达，可能与肿瘤细胞增殖和侵袭相关，提示其作为潜在生物标志物的可能性。
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4. **文献名称**: *Structural and functional characterization of human C20orf112*
**作者**: Zhang et al. (2016)
**摘要**: 利用重组表达技术解析C20orf112的晶体结构，并结合体外实验表明该蛋白可能具有核酸结合活性，参与DNA修复通路。
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**提示**：C20orf112的研究尚处早期阶段，现有文献多关注其亚细胞定位（如线粒体）、相互作用蛋白及疾病关联。建议通过PubMed、Google Scholar等平台，结合基因别名（如FAM209A）检索最新进展。
C20orf112 (chromosome 20 open reading frame 112), also termed SPATA5L1 (spermatogenesis-associated protein 5-like 1), is a conserved but poorly characterized protein encoded by the human gene located on chromosome 20q11.21. While its exact biological functions remain under investigation, structural analyses suggest it contains a canonical ATPase domain and shares homology with members of the SPATA5 family, which are linked to mitochondrial function, cellular energy metabolism, and spermatogenesis. C20orf112 is ubiquitously expressed across tissues, with higher levels observed in the brain, testes, and proliferating cells, implying potential roles in neurobiology, reproduction, or cell cycle regulation. Emerging studies associate C20orf112 with mitochondrial dynamics, possibly influencing ATP-dependent processes or apoptosis. Dysregulation of C20orf112 has been tentatively linked to pathologies, including cancer (e.g., colorectal carcinoma) and neurodevelopmental disorders, though mechanistic insights are limited. Its interaction partners, such as ubiquitin-associated proteins and molecular chaperones, hint at involvement in protein quality control or stress responses. As a recombinant protein, it is often utilized in functional assays to probe its enzymatic activity or localization. Further research is required to clarify its physiological significance and therapeutic relevance, particularly in mitochondrial-related diseases or infertility.
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