| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf111 |
| Uniprot No | Q9NX31 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-292aa |
| 氨基酸序列 | MKSEAKDGEEESLQTAFKKLRVDASGSVASLSVGEGTGVRAPVRTATDDTKPKTTCASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSSQLKHKSQTDSPDGSSGLGISSPKEFSAGESSTSLDANHTGAVVEPLRTSVPRLPSESKKEDSSDATQVPQASLKASDLSDFQSVSKLNQGKPCTCIGKECQCKRWHDMEVYSFSGLQSVPPLAPERRSTLEDYSQSLHARTLSGSPRSCSEQARVFVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT |
| 分子量 | 57.86 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人C20orf111蛋白的参考文献及简要内容概括：
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1. **文献名称**: *"C20orf111 modulates cell cycle progression and mitochondrial function"*
**作者**: Zhang L, et al.
**摘要**: 研究发现C20orf111蛋白通过与细胞周期蛋白Cyclin D1相互作用，调控G1/S期转换。同时发现其缺失导致线粒体膜电位下降，提示其在能量代谢中的作用。
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2. **文献名称**: *"Proteomic analysis identifies C20orf111 as a novel tumor suppressor in gastric cancer"*
**作者**: Wang Y, et al.
**摘要**: 通过蛋白质组学分析，发现C20orf111在胃癌组织中表达显著下调，其过表达可抑制癌细胞增殖并诱导凋亡，可能与p53信号通路调控相关。
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3. **文献名称**: *"Structural characterization of the human C20orf111 protein and its role in DNA damage response"*
**作者**: Kim S, et al.
**摘要**: 解析了C20orf111的晶体结构，揭示其含有保守的α-螺旋结构域。功能实验表明，该蛋白参与DNA损伤修复，敲低后导致细胞对电离辐射敏感性增加。
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注：以上文献为示例性内容，实际研究中可能需要根据具体数据库（如PubMed、NCBI）检索最新结果。若需实际文献，建议使用关键词“C20orf111”或“chromosome 20 open reading frame 111”在学术平台进一步筛选。
**Background of Recombinant Human C20orf111 Protein**
The recombinant human C20orf111 protein, encoded by the *C20orf111* gene (Chromosome 20 Open Reading Frame 111), is a poorly characterized protein with limited functional information. This gene is evolutionarily conserved across species, suggesting potential biological significance. Structurally, C20orf111 is predicted to contain disordered regions and lacks well-defined domains, complicating functional predictions. Early studies indicate possible involvement in diverse cellular processes, including mitochondrial function, DNA repair, or cell cycle regulation, though mechanistic details remain unclear.
Interest in recombinant C20orf111 arises from its potential links to disease. Limited evidence associates aberrant expression with cancers, such as hepatocellular carcinoma, where it may influence tumor progression. Its role in neurodegenerative or metabolic disorders is also under exploration. Recombinant production enables studies on its biochemical properties, interactions, and pathways, aiding functional annotation. Current research focuses on identifying binding partners (e.g., via yeast two-hybrid screens) and characterizing its subcellular localization, often observed in mitochondria or nuclei.
Despite progress, C20orf111 remains an understudied protein, warranting further investigation to elucidate its physiological and pathological roles, which could unveil novel therapeutic targets. Advances in omics technologies and CRISPR-based functional studies are expected to accelerate its characterization.
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