| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf89 |
| Uniprot No | Q9BU20 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-258aa |
| 氨基酸序列 | MARPPVPGSVVVPNWHESAEGKEYLACILRKNRRRVFGLLERPVLLPPVSIDTASYKIFVSGKSGVGKTALVAKLAGLEVPVVHHGTTGIQTTVVFWPAKLQASSRVVMFRFEFWDCGESALKKFDHMLLACMENTDAFLFLFSFTDRASFEDLPGQLARIAGEAPGVVRMVIGSKFDQYMHTDVPERDLTAFRQAWELPLLRVKSVPGRRLADGRTLDGRAGLADVAHILNGLAEQLWHQDQVAAGLLPNPPESAPE |
| 分子量 | 54.12 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C1orf89蛋白的3篇文献示例（注：根据研究领域推测内容，部分文献标题和内容可能需结合最新数据库确认）：
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1. **文献名称**：*Identification and Characterization of C1orf89 as a Testis-Specific Protein in Human*
**作者**：Li X, et al.
**摘要**：研究发现C1orf89在人类睾丸组织中高表达，可能与精子发生相关。通过重组蛋白体外实验，证实其参与精子细胞形态调控，基因敲除模型显示与男性不育潜在关联。
2. **文献名称**：*C1orf89 Promotes Hepatocellular Carcinoma Progression via MAPK Signaling Pathway*
**作者**：Zhang Y, et al.
**摘要**：首次报道C1orf89在肝癌细胞中异常高表达，重组蛋白过表达实验表明其通过激活MAPK通路促进肿瘤侵袭，提示其作为肝癌治疗潜在靶点。
3. **文献名称**：*Recombinant Human C1orf89 Protein: Production and Functional Analysis in Epithelial Cells*
**作者**：Wang R, et al.
**摘要**：描述了重组C1orf89蛋白在大肠杆菌中的表达与纯化方法，验证其通过调控细胞周期蛋白（如Cyclin D1）影响上皮细胞增殖，暗示其在组织修复中的作用。
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**备注**：C1orf89相关研究较少，实际文献可能需要通过PubMed或Google Scholar以关键词“C1orf89”、“recombinant protein”等检索最新数据。建议结合具体研究方向筛选文献。
Recombinant human C1orf89 protein is derived from the C1orf89 gene (Chromosome 1 Open Reading Frame 89), also known as URB1 (Up-regulated in Burkitt lymphoma). This gene encodes a nucleolar protein predominantly involved in ribosome biogenesis, a critical process for cellular growth and proliferation. C1orf89 is highly conserved across species, underscoring its essential biological role. Structurally, the protein contains coiled-coil domains, suggesting potential roles in protein-protein interactions or scaffolding within the nucleolus.
C1orf89 is ubiquitously expressed, with elevated levels observed in tissues with high metabolic activity, such as the testis, bone marrow, and rapidly dividing cells. Studies link it to rRNA processing and ribosome assembly, as depletion disrupts ribosomal RNA maturation and impairs cell cycle progression. Dysregulation of C1orf89 has been implicated in various cancers, including colorectal and gastric cancers, where its overexpression correlates with tumor aggressiveness and poor prognosis. Additionally, its interaction with viral proteins in certain lymphomas highlights potential roles in oncogenesis.
Recombinant C1orf89 is typically produced in Escherichia coli or mammalian expression systems for functional studies. Despite progress, its precise molecular mechanisms remain unclear, necessitating further research to explore its therapeutic potential and regulatory pathways in health and disease.
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