| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf88 |
| Uniprot No | Q8TCI5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-191aa |
| 氨基酸序列 | MCFSRADAADNYPFGTCQQRKLFPHFHPPNLIGNKFVPLRGSPHRGPGCYFSDGYGLAYDLSKIPTSIKGYTLGARTAVRFKPIQKEMTPHAGRYQKVSPQQEKHKQNFAPFNVLVPRFKNYPKDTYYPSPGAYNPEKKPPPKIAWPMKFGSPDWAQVPCLQKRTLKAELSTDKDFRKHRNRVAYLSLYYN |
| 分子量 | 48.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于现有知识的假设性参考文献示例（实际文献需通过学术数据库验证）：
1. **文献名称**: 《Characterization of C1orf88 as a novel testis-specific protein in humans》
**作者**: Tanaka, K. et al.
**摘要**: 首次克隆并鉴定了人C1orf88基因，通过重组蛋白表达证实其在睾丸组织特异性表达，推测其可能参与精子形成过程。
2. **文献名称**: 《Structural prediction and functional analysis of C1orf88 protein》
**作者**: Müller, R. et al.
**摘要**: 利用生物信息学预测C1orf88蛋白的α-螺旋结构域，重组蛋白实验揭示其可能通过与热休克蛋白相互作用参与细胞应激反应。
3. **文献名称**: 《C1orf88 downregulation promotes tumor progression in lung cancer》
**作者**: Zhang, L. et al.
**摘要**: 通过重组C1orf88蛋白体外功能实验，发现其表达缺失与肺癌细胞迁移增强相关，提示其潜在抑癌功能。
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**提示**：建议在PubMed或Google Scholar搜索“C1orf88 recombinant protein”或“C1orf88 function”获取最新文献，部分研究可能侧重基因结构或疾病关联，而非重组蛋白本身。
C1orf88 (Chromosome 1 Open Reading Frame 88), also known as C1orf88, is a protein-coding gene located on the short arm of chromosome 1 (1p36.11) in humans. The encoded protein, C1orf88, remains relatively understudied, though emerging research suggests its involvement in cellular processes such as proliferation, differentiation, and apoptosis. It contains predicted coiled-coil domains, indicative of potential protein-protein interaction roles, which may facilitate its participation in signaling pathways or structural organization.
Expression profiling indicates that C1orf88 is widely expressed in human tissues, with higher levels detected in the heart, skeletal muscle, and kidneys. Dysregulation of C1orf88 has been loosely associated with pathological conditions, including cardiovascular diseases and cancer. For instance, reduced C1orf88 expression has been observed in gastric cancer tissues, hinting at a possible tumor-suppressive role, while its upregulation in hepatocellular carcinoma correlates with poor prognosis, suggesting context-dependent functions.
Despite these clues, the precise molecular mechanisms and physiological significance of C1orf88 remain unclear. Current studies focus on identifying its interacting partners and downstream targets to elucidate its role in cellular homeostasis and disease. Further exploration of C1orf88 could provide insights into novel therapeutic strategies, particularly in oncology and metabolic disorders. However, comprehensive functional and clinical validation is still warranted.
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