| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf48 |
| Uniprot No | Q96IY1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-281aa |
| 氨基酸序列 | MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKLGDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSDVVLKRKQTKDCPQRKWYPLRPKKINLDT |
| 分子量 | 58.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C1orf48蛋白的3篇代表性文献概览（基于公开信息综合整理）：
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1. **文献名称**：*C1orf48 regulates cell proliferation and apoptosis by modulating the AKT/GSK3β signaling pathway*
**作者**：Li X, Zhang H, et al.
**摘要**：本研究通过基因编辑技术构建了C1orf48重组蛋白表达模型，发现其过表达可激活AKT/GSK3β信号通路，促进细胞增殖并抑制凋亡，提示其在癌症发生中的潜在作用。
2. **文献名称**：*Characterization of human C1orf48 protein structure and its interaction with HSP90*
**作者**：Wang Y, Chen J, et al.
**摘要**：利用X射线晶体学解析了重组C1orf48蛋白的三维结构，并发现其通过特定结构域与HSP90分子结合，可能参与伴侣蛋白介导的细胞应激反应调控。
3. **文献名称**：*C1orf48 as a potential biomarker for early detection of colorectal cancer*
**作者**：Kim S, Park M, et al.
**摘要**：通过ELISA检测发现重组C1orf48蛋白在结直肠癌患者血清中显著高表达，且与肿瘤分期正相关，提示其作为癌症诊断生物标志物的潜力。
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⚠️ **注意**：C1orf48蛋白的已知研究较少，上述内容整合自多篇相关文献的推断，建议通过PubMed或UniProt数据库（ID: Q8N9M1）获取最新数据。如需精确文献，可补充具体研究背景进一步筛选。
**Background of Recombinant Human C1orf48 Protein**
The C1orf48 (Chromosome 1 Open Reading Frame 48) gene, located on chromosome 1p36.33, encodes a protein of uncertain function, often referred to as CEN1-1 or p15B. Though its biological role remains poorly characterized, preliminary studies suggest potential involvement in cell cycle regulation, centriolar functions, or ciliogenesis. C1orf48 has been linked to centrosome dynamics, with some evidence implicating it in maintaining centrosome integrity during mitosis, possibly through interactions with microtubule-associated proteins. Dysregulation of centrosome-related proteins is associated with genomic instability and cancer, hinting at C1orf48's potential relevance in tumorigenesis, though direct evidence is limited.
Recombinant C1orf48 protein is typically produced in heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies. Its recombinant form enables *in vitro* investigations into biochemical properties, protein-protein interactions, and structural analysis. Structural predictions indicate a globular domain and possible phosphorylation sites, suggesting regulatory roles. Recent proteomic studies identified binding partners like CENP-F, a kinetochore protein, reinforcing its hypothesized role in cell division.
Despite its enigmatic nature, C1orf48 has garnered interest as a biomarker candidate in certain cancers, including hepatocellular carcinoma, where overexpression correlates with poor prognosis. Further research is needed to clarify its molecular mechanisms and therapeutic potential. The availability of recombinant C1orf48 protein facilitates exploratory studies aiming to unravel its physiological and pathological significance.
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