| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf38 |
| Uniprot No | Q5TEJ8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-111aa |
| 氨基酸序列 | MEGQQVILHLPLSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHIFSSLRIAATRSAAQTQGEDLARVHQGWLQYVQQDSCPQEGPQAR |
| 分子量 | 37.95 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是围绕重组人C1orf38蛋白的模拟参考文献示例（注：文献为虚构，用于示例格式）：
---
1. **标题**: *Functional Analysis of Recombinant C1orf38 in Cellular Proliferation*
**作者**: Zhang et al.
**摘要**: 研究通过重组表达C1orf38蛋白，发现其可抑制HeLa细胞的增殖，并通过RNA干扰实验验证其与p53信号通路的潜在关联。
2. **标题**: *Purification and Structural Characterization of C1orf38*
**作者**: Müller & Schmidt
**摘要**: 报道了重组C1orf38蛋白的优化表达及纯化方法，并通过X射线晶体学解析其三维结构，揭示一个新型α/β折叠域。
3. **标题**: *C1orf38 as a Biomarker in Colorectal Cancer*
**作者**: Tanaka et al.
**摘要**: 利用重组C1orf38蛋白制备抗体，发现其在结直肠癌组织中表达显著下调，提示其可能作为肿瘤抑制因子和诊断标志物。
4. **标题**: *Role of C1orf38 in Mitochondrial Function*
**作者**: Patel et al.
**摘要**: 通过重组蛋白的过表达实验，证明C1orf38通过调控线粒体膜电位影响细胞凋亡，可能参与神经退行性疾病机制。
---
**提示**：若需真实文献，建议通过PubMed或Google Scholar搜索“C1orf38 recombinant”或“C1orf38 protein function”获取，亦可结合其别名（如FLJ25404）扩展检索。
**Background of Recombinant Human C1orf38 Protein**
The human **C1orf38** protein, encoded by the *C1orf38* gene (Chromosome 1 Open Reading Frame 38), is a relatively understudied protein located on chromosome 1p36.11. It is predicted to be a small, secreted protein with a molecular weight of approximately 10–15 kDa, featuring an N-terminal signal peptide indicative of extracellular localization. Structural analyses suggest it may form homodimers via disulfide bonds.
Functionally, C1orf38 has been implicated in **spermatogenesis**, with studies linking its expression to germ cell development and male fertility. It is highly expressed in the testis, particularly in spermatogonia and early spermatocytes, and reduced levels are associated with idiopathic male infertility. Beyond reproductive biology, C1orf38 shows tissue-specific expression in organs like the brain, thyroid, and adrenal glands, though its roles in these contexts remain unclear.
Emerging evidence suggests a potential involvement in **cancer**. Aberrant C1orf38 expression has been observed in breast cancer, colorectal cancer, and gliomas, where it may act as a tumor suppressor by regulating cell proliferation or apoptosis. However, mechanistic insights are limited, and its signaling pathways or interacting partners are poorly characterized.
Recombinant C1orf38 protein is primarily used in research to explore its physiological and pathological roles. Despite its enigmatic nature, ongoing studies aim to elucidate its molecular functions, therapeutic potential, and relevance to human diseases, particularly infertility and cancer. Further investigations are required to validate its biological significance and clinical applications.
(Word count: 249)
×
