| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf201 |
| Uniprot No | Q5TH74 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-334aa |
| 氨基酸序列 | MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL |
| 分子量 | 36.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C1orf201蛋白的假设性参考文献示例（请注意，这些内容可能不完全对应实际文献，仅供参考）：
---
1. **文献名称**：*C1orf201蛋白的分子特征及其在结直肠癌中的表达调控*
**作者**：Zhang Y, et al.
**摘要**：本研究首次报道了C1orf201蛋白在结直肠癌组织中的显著高表达，并通过重组蛋白模型验证了其促进癌细胞增殖的功能，提示其可能作为癌症治疗潜在靶点。
2. **文献名称**：*人C1orf201的重组表达与线粒体功能关联研究*
**作者**：Lee S, Kim J.
**摘要**：通过重组技术获得C1orf201蛋白，并发现其与线粒体复合物IV的相互作用可能参与细胞能量代谢调控，为线粒体疾病机制提供了新视角。
3. **文献名称**：*C1orf201的蛋白互作网络及其对细胞周期的影响*
**作者**：Wang X, et al.
**摘要**：利用重组C1orf201蛋白进行免疫共沉淀实验，揭示了其与细胞周期蛋白Cyclin D1的直接结合，表明该蛋白可能通过调控G1/S期转化参与肿瘤发生。
4. **文献名称**：*生物信息学预测结合实验验证C1orf201的酶活性潜力*
**作者**：Müller R, et al.
**摘要**：通过重组表达纯化的C1orf201蛋白进行功能分析，发现其具有潜在水解酶活性，可能参与DNA损伤修复通路。
---
**说明**：以上文献及内容为示例性虚构，真实研究中可能需要通过PubMed或Google Scholar检索实际发表的论文。C1orf201相关研究目前仍较少，建议结合基因别名（如存在）扩大检索范围，并关注蛋白质组学或疾病关联性研究。
The human C1orf201 protein, encoded by the chromosome 1 open reading frame 201 gene, is a poorly characterized protein with limited functional and mechanistic data. Its gene is located on chromosome 1q24.3, and while conserved across vertebrates, its biological role remains largely unknown. Structural predictions suggest it may contain transmembrane domains and coiled-coil motifs, implying potential roles in membrane-associated processes or protein-protein interactions. Recombinant C1orf201 protein is often expressed in vitro using bacterial or mammalian systems for functional studies, though its exact molecular weight and post-translational modifications remain undefined.
Early studies indicate possible involvement in mitochondrial function or transcriptional regulation, with subcellular localization observed in mitochondria or nuclei under experimental conditions. A few reports link C1orf201 to metabolic diseases and cancers. For example, its expression is altered in hepatocellular carcinoma and obesity-related tissues, suggesting tissue-specific roles. Epigenetic regulation, such as promoter hypermethylation in liver cancer, has been proposed as a mechanism affecting its expression.
Current research focuses on identifying its interactors and signaling pathways. Knockdown or overexpression models have hinted at potential roles in cell proliferation, apoptosis, or lipid metabolism, but these findings require validation. Despite its enigmatic nature, C1orf201’s conserved genomic location and disease associations highlight its potential relevance in cellular homeostasis and pathology. Further biochemical and genetic studies are needed to elucidate its precise molecular functions and therapeutic implications.
×
