| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf189 |
| Uniprot No | Q5VU69 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-101aa |
| 氨基酸序列 | MSVEKMTKVEESFQKAMGLKKTVDRWRNSHTHCLWQMALGQRRNPYATLRMQDTMVQELALAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYVERF |
| 分子量 | 11.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于学术文献的假设性示例（实际文献需通过PubMed等平台查询确认）：
1. **"Functional characterization of C1orf189 as a novel regulator of cellular stress response"**
- 作者：Zhang Y, et al.
- 摘要：研究首次报道C1orf189蛋白在氧化应激条件下的表达上调，并通过调控MAPK信号通路参与细胞凋亡抑制，提示其可能作为潜在癌症治疗靶点。
2. **"C1orf189 interacts with microtubule-associated proteins and modulates neuronal development"**
- 作者：Liu X, et al.
- 摘要：发现C1orf129（原文或为同源基因命名差异）通过与Tau蛋白相互作用影响微管稳定性，可能参与神经退行性疾病病理过程。
3. **"Structural prediction and homology analysis of human C1orf189 protein"**
- 作者：Wang R, et al.
- 摘要：利用生物信息学预测C1orf189的α-螺旋结构域及潜在磷酸化位点，提示其可能具备酶或支架蛋白功能。
4. **"High expression of C1orf189 correlates with poor prognosis in gastric cancer"**
- 作者：Chen H, et al.
- 摘要：通过组织芯片分析显示C1orf189在胃癌中高表达，并与患者生存率负相关，机制可能涉及上皮间质转化（EMT）调控。
**说明**：以上为模拟参考文献，C1orf189的研究尚处早期阶段，建议通过UniProt（ID: Q8N9W6）获取已知结构/功能信息，或通过PubMed检索最新文献。
C1orf189 (Chromosome 1 Open Reading Frame 189), also known as MROH1, is a poorly characterized protein encoded by a gene located on the short arm of chromosome 1 (1p36.11). Despite limited functional studies, bioinformatic analyses suggest it is a conserved, intrinsically disordered protein with potential roles in cytoskeletal organization or intracellular trafficking. Its amino acid sequence contains predicted coiled-coil domains and a C-terminal transmembrane region, implying membrane association or protein-protein interactions.
The recombinant human C1orf189 protein is typically produced via heterologous expression in systems like *E. coli* or mammalian cells, enabling biochemical and functional studies. Recombinant variants often include affinity tags (e.g., His-tag) for purification. While its physiological function remains unclear, preliminary evidence links C1orf189 to cancer progression. For example, upregulated expression has been observed in hepatocellular carcinoma and glioblastoma, suggesting potential involvement in tumorigenesis or metastasis.
Further research is needed to define its molecular mechanisms, interactome, and relevance to cellular pathways. Current interest focuses on its hypothesized role in ciliogenesis and vesicular transport, supported by homology modeling and co-expression networks. Therapeutic exploration, including its utility as a biomarker or drug target, remains speculative but underscores the growing attention to understudied proteins in precision medicine.
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