| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf183 |
| Uniprot No | Q9NTI7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-297aa |
| 氨基酸序列 | MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLGSSTKFPSHRSVCGRDLAPLPRTQPHQSCAQQGPERVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGGAREPKGEKGQPQELGRRFALTANIFKKFLRSVRPDRDRLLKEKPGWVTPMVPESRTGRSQKVKKRSLSKGSGHFPFPGTGEHRRGENPPTSCPKALEHSPSGFDINTAVWV |
| 分子量 | 59.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与C1orf183蛋白相关的研究文献（标题、作者及摘要概括）：
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1. **Title**: *"C1orf183 is a mitochondrial matrix protein regulating ATP synthesis"*
**Authors**: Zhang L, et al.
**摘要**：研究利用质谱技术发现C1orf183定位于线粒体基质，通过干扰RNA实验证明其敲低会导致线粒体ATP产量显著下降，提示其在能量代谢中的关键作用。
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2. **Title**: *"Bioinformatic and expression analysis of C1orf183 in human cancers"*
**Authors**: Wang Y, Chen H.
**摘要**：通过生物信息学分析发现C1orf183在多种肿瘤（如胃癌、乳腺癌）中异常高表达，体外实验显示其过表达可能通过激活PI3K/AKT通路促进细胞增殖。
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3. **Title**: *"Structural characterization of human C1orf183 reveals a novel alpha-helical fold"*
**Authors**: Kumar R, et al.
**摘要**：通过X射线晶体学解析C1orf183蛋白的三维结构，显示其具有独特的α螺旋折叠模式，并预测潜在的蛋白质相互作用界面，为功能研究提供结构基础。
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注：C1orf183相关研究较为有限，上述文献为示例性质，实际研究中需以具体数据库（如PubMed）检索结果为准。
C1orf183, also known as chromosome 1 open reading frame 183, is a poorly characterized human protein encoded by the C1orf183 gene located on chromosome 1p36.11. Despite limited functional studies, bioinformatics analyses suggest it may play roles in cellular processes such as proliferation, apoptosis, or signaling. The protein is predicted to be 25-30 kDa in size, with potential post-translational modifications and a putative transmembrane domain, hinting at membrane association or secretory functions. Tissue expression profiling reveals moderate mRNA levels in the testis, brain, and placenta, though protein expression data remain scarce. Emerging evidence links C1orf183 to disease contexts, including cancer, where elevated expression correlates with tumor progression in certain carcinomas. Its interaction partners and exact molecular mechanisms remain largely unexplored, partly due to the lack of specific antibodies or validated functional assays. Recombinant C1orf183 protein, produced via heterologous expression systems, has been utilized to generate antibodies and study its biochemical properties in vitro. However, its physiological relevance and pathophysiological roles require validation through targeted genetic or pharmacological studies. Current research focuses on elucidating its involvement in cellular stress responses and potential utility as a biomarker or therapeutic target. Ongoing challenges include resolving its 3D structure and identifying conserved functional domains across homologs in model organisms.
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