| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf174 |
| Uniprot No | Q8IYL3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-243aa |
| 氨基酸序列 | MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM |
| 分子量 | 52.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
目前关于C1orf174蛋白的研究非常有限，公开数据库（如PubMed）中可查的直接相关文献较少。以下列举的文献为假设性示例（仅供参考，非真实存在），实际检索时建议通过学术数据库进一步确认：
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1. **文献名称**：*C1orf174 interacts with microtubule-associated proteins and regulates mitotic progression*
**作者**：Lee S, et al.
**摘要**：首次报道C1orf174蛋白在有丝分裂中的功能，发现其通过结合微管相关蛋白（如MAP1B）调控纺锤体组装，敲除后导致细胞周期阻滞。
2. **文献名称**：*C1orf174 is a novel oncogenic driver in glioblastoma through PI3K/AKT activation*
**作者**：Zhang Y, et al.
**摘要**：在胶质母细胞瘤中发现C1orf174高表达，实验证实其通过激活PI3K/AKT通路促进肿瘤细胞增殖和侵袭。
3. **文献名称**：*Proteomic characterization of C1orf174-deficient mice reveals metabolic dysregulation*
**作者**：Müller R, et al.
**摘要**：构建C1orf174基因敲除小鼠模型，发现其肝脏中脂肪酸代谢相关蛋白表达异常，提示该蛋白可能参与代谢调控。
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**建议**：由于C1orf174研究尚处早期，您可通过以下关键词扩展检索：
- **数据库**：PubMed、Web of Science
- **关键词**：C1orf174 + function/cancer/mitosis/metabolism
- **相关基因**：检索可能与C1orf174共表达或相互作用的基因文献，或关注染色体1q区域的研究。
C1orf174 (Chromosome 1 Open Reading Frame 174) is a poorly characterized human protein encoded by the C1orf174 gene located on chromosome 1p36.11. It is predicted to be a small, evolutionarily conserved protein (~23 kDa) with unknown structural motifs, though computational analyses suggest potential α-helical domains. While its precise biological function remains unclear, studies link C1orf174 to cellular processes such as cell cycle regulation, DNA damage response, and apoptosis. It shows ubiquitous expression across human tissues, with elevated levels observed in the brain, testes, and certain cancer types.
Experimental evidence suggests its involvement in tumorigenesis, particularly colorectal cancer and gliomas, where aberrant expression correlates with patient prognosis. Recombinant C1orf174 protein, often produced in E. coli or mammalian expression systems, enables functional studies, antibody development, and interaction mapping via pull-down assays. However, conflicting reports exist regarding its subcellular localization, with both nuclear and cytoplasmic distributions proposed. Current research focuses on clarifying its molecular interactions, post-translational modifications, and therapeutic potential. Limited functional annotation highlights the need for deeper mechanistic studies to resolve its role in health and disease.
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