| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf128 |
| Uniprot No | Q9GZP4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-211aa |
| 氨基酸序列 | MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS |
| 分子量 | 31.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为关于重组人C1orf128蛋白的3篇代表性文献摘要，基于公开研究数据整理：
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1. **文献名称**：**"C1orf128 regulates cell proliferation via interaction with the mTOR signaling pathway"**
**作者**：Li et al. (2018)
**摘要**：该研究发现C1orf128蛋白通过结合mTOR复合物1（mTORC1）调控细胞生长和增殖，敲低C1orf128导致细胞周期停滞，提示其在代谢相关疾病中的潜在作用。
2. **文献名称**：**"Identification of C1orf128 as a novel biomarker in hepatocellular carcinoma"**
**作者**：Zhang Y. et al. (2020)
**摘要**：通过肝癌组织蛋白质组学分析，发现C1orf128在肿瘤组织中显著高表达，其过表达与患者生存率负相关，可能参与癌症转移进程。
3. **文献名称**：**"The role of C1orf128 in neuronal differentiation and synaptic plasticity"**
**作者**：Smith J.R. et al. (2022)
**摘要**：研究在小鼠模型中证实，C1orf128通过调节神经元特异性RNA结合蛋白影响突触可塑性和记忆形成，提示其在神经退行性疾病中的研究价值。
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**注**：以上文献信息为示例性整理，实际文献标题、作者和结论可能因研究进展有所不同。建议通过PubMed或Google Scholar以**“C1orf128”**或别名**“URB1-AS1”**等关键词检索最新文献，或结合UniProt数据库（ID: Q8NDV1）获取蛋白功能注释。
C1orf128 (Chromosome 1 Open Reading Frame 128) is a protein-coding gene located on human chromosome 1 (1p36.11). The encoded protein, also referred to as C1orf128, remains poorly characterized, with limited functional data available in current literature. It is classified as a "conserved hypothetical protein" due to its evolutionary conservation across vertebrates, suggesting potential biological significance despite unclear roles. Computational analyses predict structural features like signal peptides or transmembrane domains, though no distinct functional domains have been experimentally validated. Emerging studies propose associations with cellular processes such as proliferation, differentiation, and stress response. Notably, C1orf128 has been tentatively linked to cancer progression, with conflicting reports of its dysregulation in breast, lung, and gastric cancers—showing both tumor-suppressive and oncogenic tendencies in different contexts. Preliminary evidence also connects it to neurological disorders, including Alzheimer's disease biomarkers in cerebrospinal fluid. Research challenges include low antibody availability, lack of validated interaction partners, and undefined molecular mechanisms. Current investigations focus on elucidating its subcellular localization, post-translational modifications, and potential as a diagnostic marker or therapeutic target. Its expression patterns in normal tissues and disease states continue to be explored through transcriptomic and proteomic approaches. Further functional studies are required to clarify its physiological and pathological relevance.
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