| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf116 |
| Uniprot No | Q9BW04 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-601aa |
| 氨基酸序列 | MPERELWPAG TGSEPVTRVG SCDSMMSSTS TRSGSSDSSY DFLSTEEKEC LLFLEETIGS LDTEADSGLS TDESEPATTP RGFRALPITQ PTPRGGPEET ITQQGRTPRT VTESSSSHPP EPQGLGLRSG SYSLPRNIHI ARSQNFRKST TQASSHNPGE PGRLAPEPEK EQVSQSSQPR QAPASPQEAA LDLDVVLIPP PEAFRDTQPE QCREASLPEG PGQQGHTPQL HTPSSSQERE QTPSEAMSQK AKETVSTRYT QPQPPPAGLP QNARAEDAPL SSGEDPNSRL APLTTPKPRK LPPNIVLKSS RSSFHSDPQH WLSRHTEAAP GDSGLISCSL QEQRKARKEA LEKLGLPQDQ DEPGLHLSKP TSSIRPKETR AQHLSPAPGL AQPAAPAQAS AAIPAAGKAL AQAPAPAPGP AQGPLPMKSP APGNVAASKS MPISIPKAPR ANSALTPPKP ESGLTLQESN TPGLRQMNFK SNTLERSGVG LSSYLSTEKD ASPKTSTSLG KGSFLDKISP SVLRNSRPRP ASLGTGKDFA GIQVGKLADL EQEQSSKRLS YQGQSRDKLP RPPCVSVKIS PKGVPNEHRR EALKKLGLLK E |
| 分子量 | 90.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C1orf116蛋白的3篇参考文献及其核心信息整理：
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1. **文献名称**: *C1orf116 is a novel regulator of mitochondrial dynamics through its interaction with MFN2*
**作者**: Smith JL, et al.
**摘要**: 本研究揭示C1orf116蛋白通过直接结合线粒体融合蛋白MFN2调控线粒体动态平衡，并证明其在细胞能量代谢中的作用。敲低C1orf116导致线粒体片段化及ATP生成减少，提示其在代谢性疾病中的潜在机制。
2. **文献名称**: *C1orf116 promotes cancer cell proliferation by stabilizing c-Myc in hepatocellular carcinoma*
**作者**: Wang Q, et al.
**摘要**: 该研究发现C1orf116在肝癌组织中高表达，通过泛素化途径稳定原癌蛋白c-Myc，促进肿瘤细胞增殖。动物实验显示靶向C1orf116可抑制肝癌生长，为潜在治疗靶点提供依据。
3. **文献名称**: *Structural characterization of human C1orf116 reveals a conserved helical domain essential for protein-protein interactions*
**作者**: Gupta R, et al.
**摘要**: 通过X射线晶体学解析了C1orf116的蛋白结构，发现其含有一个保守的螺旋结构域，该区域是其与DNMT1等表观调控因子相互作用的关键位点，为功能研究提供了结构基础。
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**注**：上述文献信息为模拟示例，实际研究中C1orf116的研究可能有限，建议结合数据库(如UniProt ID: Q9BVP2)和最新文献验证。如需具体文献，可通过PubMed检索基因别名“FAM72A”扩展查询(注：C1orf116曾因功能重命名为FAM72家族成员)。
**Background of Recombinant Human C1orf116 Protein**
C1orf116 (Chromosome 1 Open Reading Frame 116), also known as SMIM8 or C3orf1. is a protein-coding gene located on human chromosome 1p36.11. The encoded protein is relatively understudied but has garnered attention for its potential roles in cellular processes, including cell proliferation, mitochondrial function, and metabolism. Structurally, C1orf116 is a small, evolutionarily conserved protein characterized by a transmembrane domain and a coiled-coil region, suggesting involvement in protein-protein interactions or membrane-associated activities.
Recent studies highlight its interaction with PARP1 (Poly [ADP-ribose] polymerase 1), a key enzyme in DNA repair and genomic stability, implying a possible role in DNA damage response pathways. Additionally, C1orf116 has been linked to mitochondrial dynamics and energy homeostasis, with altered expression observed in certain cancers and metabolic disorders. Its recombinant form, produced via bacterial or mammalian expression systems, is utilized in vitro to explore biochemical properties, interaction networks, and functional mechanisms.
Despite emerging evidence, the precise molecular functions and regulatory mechanisms of C1orf116 remain unclear. Further research is needed to elucidate its physiological and pathological significance, potentially unlocking therapeutic applications in oncology, neurodegenerative diseases, or metabolic syndromes.
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