| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf112 |
| Uniprot No | Q9NSG2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-853aa |
| 氨基酸序列 | MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQNLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVHCKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIVIHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSFHSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQLYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDLPCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSGELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSANMITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFMAPPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRSRTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQQTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIPEAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG |
| 分子量 | 96.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C1orf112** 的模拟参考文献示例(真实文献需核实)：
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1. **Title**: *Structural characterization of C1orf112 reveals a putative role in DNA repair*
**Authors**: Müller, J.P., Ritter, S.
**Summary**：本研究首次解析了C1orf112蛋白的三维结构，发现其具有核酸结合结构域，暗示其可能参与DNA损伤修复过程，并通过体外实验验证了其与DNA双链断裂标志物的相互作用。
2. **Title**: *C1orf112 interacts with POLG and regulates mitochondrial genome stability*
**Authors**: Yamamoto, K., et al.
**Summary**：研究发现C1orf112蛋白与线粒体DNA聚合酶γ(POLG)直接结合，敲低C1orf112导致线粒体DNA复制异常，提示其在维持线粒体基因组稳定性中的潜在功能。
3. **Title**: *C1orf112 expression correlates with cancer progression and prognosis in glioblastoma*
**Authors**: Chen, L., Wang, H.
**Summary**：通过分析肿瘤数据库和患者样本，发现C1orf112在胶质母细胞瘤中高表达，且与肿瘤侵袭性呈正相关，可能通过调控细胞周期相关通路促进癌细胞增殖。
4. **Title**: *Functional annotation of C1orf112 through CRISPR-Cas9 screening*
**Authors**: Khan, S., et al.
**Summary**：全基因组CRISPR筛选发现C1orf112缺失导致细胞对拓扑异构酶抑制剂敏感，推测其可能参与调控DNA拓扑结构或复制压力应答机制。
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**注意**：上述文献为示例性质，建议通过 **PubMed** 或 **Google Scholar** 以“C1orf112”为关键词查询真实文献。该蛋白研究仍处于早期阶段，现有文献可能集中于生信预测或初步功能验证。
**Background of Recombinant Human Uncharacterized Protein C1orf112**
C1orf112 (Chromosome 1 Open Reading Frame 112) is a conserved yet poorly understood protein encoded by a gene located on the short arm of human chromosome 1 (1p36.11). Despite its presence across vertebrates, the molecular function, physiological role, and clinical relevance of C1orf112 remain largely uncharacterized. Bioinformatics analyses suggest it is a cytoplasmic/nuclear protein with potential α-helical domains, but experimental validation is limited. Limited studies indicate possible associations with DNA repair pathways, cell cycle regulation, or microtubule dynamics, inferred from interactions with proteins like DNA-PK and tubulin-binding factors.
Dysregulation of C1orf112 has been weakly linked to cancers (e.g., gastric and lung cancers) and neurodevelopmental disorders, though mechanistic insights are lacking. Recombinant C1orf112. typically produced in *E. coli* or mammalian systems, enables structural studies (e.g., crystallography) and functional assays to probe its interactions or enzymatic properties. Its conserved sequence implies evolutionary importance, yet no disease-specific mutations or biomarkers have been conclusively identified. Further research is critical to elucidate its role in cellular processes and potential therapeutic applications. Current work focuses on resolving its 3D structure, identifying binding partners, and exploring its relevance in genome stability or disease pathways.
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