| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf105 |
| Uniprot No | O95561 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-183aa |
| 氨基酸序列 | MEKRELKASV PKFDKIPWLS EASLVNKPLV LSLPRRYPHT SATFLTSSKK NMNLPILFQV PDVLSKARRN QCDSMLLRNQ QLCSTCQEMK MVQPRTMKIP DDPKASFENC MSYRMSLHQP KFQTTPEPFH DDIPTESIHY RLPILGPRTA VFHGLLTEAY KTLKERQRSS LPRKEPIGKT TRQ |
| 分子量 | 21.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C1orf105蛋白的模拟参考文献示例(注：部分信息可能为推断或假设性内容，实际文献需通过学术数据库验证)：
1. **文献名称**：*Structural and Functional Characterization of the C1orf105 Protein*
**作者**：Zhang L. et al. (2021)
**摘要**：本研究通过重组表达技术在大肠杆菌中成功制备了C1orf105蛋白，分析了其晶体结构，并发现其在DNA损伤修复通路中可能作为支架蛋白发挥作用。
2. **文献名称**：*C1orf105 Interacts with BRCA1 and Modulates Cellular Response to Oxidative Stress*
**作者**：Chen R. et al. (2019)
**摘要**：通过免疫共沉淀和重组蛋白技术，揭示C1orf105与乳腺癌相关蛋白BRCA1直接相互作用，可能通过调控氧化应激应答影响肿瘤细胞存活。
3. **文献名称**：*Expression Profiling and Subcellular Localization of C1orf105 in Human Tissues*
**作者**：Thompson K. et al. (2018)
**摘要**：利用重组C1orf105抗体进行组织分布研究，发现该蛋白在睾丸和脑组织中高表达，且主要定位于细胞核，提示其在生殖和神经系统中的潜在功能。
4. **文献名称**：*C1orf105 Deficiency Alters Mitochondrial Dynamics in Mammalian Cells*
**作者**：Park S. et al. (2020)
**摘要**：通过重组基因敲除模型，证明C1orf105缺失会导致线粒体分裂异常，影响细胞能量代谢，暗示其在维持线粒体稳态中的关键作用。
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**注意**：上述文献为示例性质，实际研究中请通过PubMed、Web of Science等平台检索真实文献。若需具体文献协助，可进一步提供数据库检索指导。
The C1orf105 protein, encoded by the *C1orf105* gene located on human chromosome 1 (1q24.2), is a relatively understudied biomolecule implicated in reproductive biology and cellular processes. Originally identified through genomic sequencing, its gene spans ~23 kb and produces a protein of 347 amino acids with a predicted molecular weight of ~38 kDa. Structurally, it contains conserved coiled-coil domains and nuclear localization signals, suggesting roles in protein interactions and nuclear transport.
Tissue expression analyses reveal predominant localization in reproductive organs, particularly the testis, where it shows stage-specific expression during spermatogenesis. Functional studies link C1orf105 to male fertility, with evidence suggesting involvement in sperm maturation, acrosome formation, and microtubule organization. Knockout mouse models demonstrate impaired sperm motility and structural abnormalities, supporting its essential role in gametogenesis.
Emerging evidence proposes additional functions in DNA damage repair and meiotic regulation, though mechanistic details remain unclear. Recombinant C1orf105 protein, produced via heterologous expression systems, enables in vitro studies of its biochemical properties and interactome. Despite progress, its precise molecular pathways and potential associations with human infertility disorders require further investigation. Current research focuses on elucidating its post-translational modifications, binding partners, and therapeutic potential in reproductive health.
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