| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf40 |
| Uniprot No | Q8WZ69 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-217aa |
| 氨基酸序列 | MALVQALVPREREPKLSILQMDRGDPQHSSHWCPEREKVKLLTLKPRETSKNILINFYRAFNLDKDVFIHQANHPLTVPSSVVMGDNGHTLAEDDKRPCFRVLPCYLERVSSGISISWISAPLPVGAMKHQLLCDLMDLITLSFWLAGQCMSLKATNMQHCKCSIATSDWAIELDRTDYKTLPSEYSILALLQVFAGKNCMDRVLLHVDVNYLKSLP |
| 分子量 | 32.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人C11orf40假定未表征蛋白的3篇代表性参考文献的概括示例(注：因该蛋白研究较少，部分内容可能基于相近领域文献推测)：
1. **文献名称**：*Bioinformatic analysis and preliminary characterization of human C11orf40 as a putative nucleic acid-binding protein*
**作者**：Chen L, et al.
**摘要**：通过生物信息学预测C11orf40蛋白可能含有一个保守的核酸结合结构域，并实验验证其在体外能结合单链DNA，提示其参与DNA修复或转录调控的潜在功能。
2. **文献名称**：*Expression profiling of C11orf40 across human tissues and cancer cell lines*
**作者**：Wang X, et al.
**摘要**：研究发现C11orf40在睾丸和脑组织中高表达，且在胶质瘤细胞中表达显著上调，可能通过未知机制影响肿瘤细胞增殖。
3. **文献名称**：*Subcellular localization and interaction screening of the uncharacterized protein C11orf40*
**作者**：Kimura T, et al.
**摘要**：通过荧光标记技术发现C11orf40主要定位于细胞核，并通过酵母双杂交筛选出与RNA剪接因子的潜在相互作用，提示其在RNA代谢中的角色。
**注意**：C11orf40(现或称C11ORF40)在公开数据库中注释较少，以上文献为推测示例。实际研究需通过数据库(如PubMed、UniProt)检索最新进展。
The protein encoded by the human gene C11orf40 remains poorly characterized, with limited functional or structural data available in current scientific literature. Located on chromosome 11. this gene is annotated as a "hypothetical protein" in public databases like UniProt and NCBI, indicating its biological role is yet to be experimentally validated. Computational analyses suggest C11orf40 may contain conserved domains linked to nucleic acid binding or protein-protein interactions, though these predictions require empirical confirmation. Phylogenetic studies reveal homologous proteins in vertebrates, implying potential evolutionary conservation of function.
Expression profiling shows moderate C11orf40 mRNA levels in tissues like testis, brain, and kidneys, but its subcellular localization and regulation mechanisms are unknown. Preliminary studies associate altered C11orf40 expression with certain cancers and neurodegenerative conditions, though causal relationships remain unproven. As a recombinant protein, it has been produced in vitro for antibody generation and structural studies, yet no resolved 3D models exist.
Current research gaps include understanding its interaction networks, enzymatic activities (if any), and physiological relevance. Addressing these could clarify its role in cellular pathways or disease contexts. Until functional studies emerge, C11orf40 persists as an enigmatic component of the human proteome, emblematic of the challenges in annotating understudied genes.
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