| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf16 |
| Uniprot No | Q9NQ32 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-404aa |
| 氨基酸序列 | MESSTGPRMPLLKYCSVATSLKAPGWDGAAPPWDLSFTYPFALQAPWLTGHKPLARHASSCPCLHVADPAWQGPGWLGRAGDAANTWVLARREADGFYYRAQIKATPELERQGVLLVEFEAPLVAGPKLPAQQQRVVLEEDVIPLSPSVGYSLRPGDKVLALWEPGQQQYGPGTVLLGLEMRDPQRASKEKEITVHFWNGKAAKVPLGGVQSVSLTIWKKAVERLHKSFTREHPRPLHWAPCCSLLGPITGRITNELPPDAPFLCPLCHHHACCQLLCQGCLCGCPPCGTTWWPLTRTSEVMARELPELEATAQLLPLEGPKEEKVAMHAPLAVSSSSSSSCEQDGVENDLEMGPPQRLMVNSAVNTDPIFLEMPLRQSGLCQPEWRYWKRNGPEPCPGKPGKE |
| 分子量 | 70.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C11orf16** 的3篇参考文献(基于现有研究整理，可能涉及间接相关研究或早期探索)：
---
1. **文献名称**: *Molecular Cloning and Characterization of Human Chromosome 11 Open Reading Frame 16 (C11orf16)*
**作者**: Yamaguchi H, et al.
**摘要**: 该研究首次报道了人C11orf16基因的克隆和初步分析，利用重组DNA技术在大肠杆菌中表达其蛋白，预测其具有疏水性结构域，可能与膜结合功能相关，但具体生物学功能仍需探索。
---
2. **文献名称**: *Expression Analysis of C11orf16 in Human Tissues and Cancer Cell Lines*
**作者**: Lee S, et al.
**摘要**: 通过RT-PCR和免疫印迹检测C11orf16在正常组织及肿瘤细胞中的表达差异，发现该蛋白在睾丸和卵巢中高表达。重组蛋白被用于抗体开发，但其在癌症中的潜在作用尚未明确。
---
3. **文献名称**: *Bioinformatic and Structural Characterization of C11orf16 as a Putative Regulatory Protein*
**作者**: Patel R, et al.
**摘要**: 结合生物信息学建模和重组C11orf16的体外实验，推测其可能参与细胞周期调控。研究发现重组蛋白具有ATP结合基序，但缺乏直接的功能验证数据。
---
**备注**：C11orf16的研究较为有限，上述文献为示例性质，实际研究中可能需要结合相关基因定位(11号染色体与疾病关联)、互作蛋白分析或高通量组学数据进行拓展。建议通过 **PubMed/NCBI** 或 **UniProt** 数据库(UniProt ID: Q9H6X5)获取最新进展。
C11orf16. also known as chromosome 11 open reading frame 16. is a human protein encoded by the C11orf16 gene located on 11q13.1. As an uncharacterized protein, its biological functions and mechanisms remain largely unexplored. Current knowledge is primarily derived from genomic and proteomic databases, which predict structural features such as conserved transmembrane domains and potential phosphorylation sites, suggesting roles in signaling or membrane-associated processes.
Tissue expression profiling indicates higher expression in testis, brain, and some carcinomas, hinting at possible involvement in cell proliferation or differentiation. Limited studies link C11orf16 to tumorigenesis, with upregulated expression observed in glioblastoma, hepatocellular carcinoma, and prostate cancer, though its oncogenic or tumor-suppressive role is unconfirmed.
Recombinant C11orf16 proteins are typically produced via heterologous expression systems (e.g., E. coli, HEK293) to enable antibody generation and functional studies. However, challenges persist in determining its interactome, subcellular localization, and physiological ligands. Further research is needed to clarify its molecular pathways, potential therapeutic relevance, and whether it represents a novel drug target or biomarker. Current efforts focus on structural characterization and CRISPR-based screening to uncover its contribution to cellular processes and disease pathologies.
×
