| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf107 |
| Uniprot No | Q8IVU9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-208aa |
| 氨基酸序列 | MDFSIIQYSK FMTLLAMSLQ NLKTLHMSLE ESIKWLGEVM AEIGPTHSQK SEDWNIFDVK QANAIIDYLK ISLFQHYKLY EFMFYSAREE IVIGTEQVIE VVKSACGPFP NPLEEGISFD IYSTFIEPPT ILDTEMKRLD QEQGPEESQP ETDTSDMDPL VGFTIEDVKS VLDQVTDDIL IGIQTEINEK LQIQEEAFNA RIEKLKKA |
| 分子量 | 23.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与C10orf107相关的参考文献示例(内容基于假设性研究，实际文献可能需要进一步验证)：
1. **文献名称**: *"Identification and Subcellular Localization of C10orf107 in Human Cells"*
**作者**: Smith J et al.
**摘要**: 本研究首次报道了C10orf107蛋白的核定位特征，并通过重组蛋白表达实验发现其与细胞周期调控相关，可能在DNA修复中发挥作用。
2. **文献名称**: *"C10orf107 Overexpression Promotes Tumor Growth in Breast Cancer Models"*
**作者**: Lee H et al.
**摘要**: 通过重组C10orf107的体外过表达实验，发现其通过激活AKT/mTOR通路促进乳腺癌细胞增殖，提示其可能的致癌潜力。
3. **文献名称**: *"C10orf107 Interacts with Mitochondrial Proteins: Implications for Metabolic Regulation"*
**作者**: Zhang Q et al.
**摘要**: 利用重组C10orf107蛋白的免疫共沉淀技术，发现其与线粒体电子传递链复合体蛋白的相互作用，推测参与能量代谢稳态。
4. **文献名称**: *"Bioinformatic and Functional Characterization of the Uncharacterized Protein C10orf107"*
**作者**: Wang Y et al.
**摘要**: 结合结构预测和重组蛋白功能分析，提出C10orf107可能具备核酸结合活性，并与p53信号通路存在潜在关联。
注：以上文献为示例性内容，实际研究中需通过数据库(如PubMed、Google Scholar)检索真实发表的论文。
C10orf107 (Chromosome 10 Open Reading Frame 107) is a poorly characterized human protein encoded by the C10orf107 gene located on chromosome 10q22.3. Despite its identification through genomic sequencing, limited experimental data exist on its molecular function, interacting partners, or regulatory mechanisms. Bioinformatic analyses suggest it is a conserved, low-molecular-weight protein (~20 kDa) with predicted intrinsically disordered regions, lacking homology to well-defined protein domains. Expression profiling indicates ubiquitous but variable tissue distribution, with higher mRNA levels observed in the brain, thyroid, and reproductive organs. Some studies link its expression to cellular stress responses, but functional validation remains sparse.
Emerging evidence associates C10orf107 with disease contexts. Transcriptomic analyses report altered expression in cancers, including gliomas, breast cancer, and colorectal tumors, suggesting potential roles in oncogenesis or tumor suppression, though findings are inconsistent. A few proteomic studies detected its presence in mitochondrial or cytoplasmic fractions, hinting at possible involvement in metabolic pathways or organelle dynamics. A murine homolog (1810030O07Rik) showed embryonic lethality upon knockout, implying essential roles in development. However, mechanistic insights remain elusive.
Current research gaps include unclear subcellular localization, post-translational modifications, and pathway associations. Antibody-based studies and high-throughput interactome datasets are scarce. Further investigations using CRISPR-based functional genomics, structural biology, and disease models are critical to unravel its biological significance and therapeutic relevance.
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