关键信息
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基因名
MYSM1
- 应用
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别名
2A-DUB; 2ADUB; Histone H2A deubiquitinase; Histone H2A deubiquitinase MYSM1; KIAA1915; Myb like SWIRM and MPN domains 1; Myb like. SWIRM and MPN domain containing protein; Myb like. SWIRM and MPN domains 1; Myb-like; Myb-like. SWIRM and MPN domains 1; MYSM 1; mysm1; MYSM1 Myb-like. SWIRM and MPN domains 1; MYSM1_HUMAN; RP4-592A1.1; SWIRM and MPN domain-containing protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5VVJ2
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表达区间
1-828 aa
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氨基酸序列
MAAEEADVDIEGDVVAAAGAQPGSGENTASVLQKDHYLDSSWRTENGLIPWTLDNTISEENRAVIEKMLLEEEYYLSKKSQPEKVWLDQKEDDKKYMKSLQKTAKIMVHSPTKPASYSVKWTIEEKELFEQGLAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDKETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELAKRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGVTEENCTKELLM
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分子量
117.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MYSM1, or Myb-like, SWIRM, and MPN domain-containing protein 1, is a member of the MPN+ (MPR1/Map7 family) domain-containing protein family and plays a crucial role in various cellular processes, including DNA damage repair, cell cycle regulation, and epigenetic modifications. The study of MYSM1 has gained significance due to its involvement in the regulation of gene expression through deubiquitination and the modulation of histone modifications, indicating its potential role in cancer biology and stem cell maintenance. Research has shown that MYSM1 acts as a positive regulator of certain tumor suppressors and is implicated in the progression of various malignancies, suggesting its potential as a therapeutic target. Furthermore, MYSM1's function in the immune response and its ability to influence the differentiation of immune cells highlights its relevance in both tumor immunology and autoimmunity research. As scientists delve deeper into the structural and functional characteristics of MYSM1, including its interactions with other key regulatory proteins and its post-translational modifications, there is a growing interest in exploring its therapeutic potential and understanding its contributions to disease pathogenesis, particularly in oncology and regenerative medicine. Overall, the ongoing investigation of MYSM1 represents a promising frontier in molecular biology, opening avenues for innovative strategies in the treatment of diseases linked to its dysregulation.
