关键信息
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基因名
RAB7A
- 应用
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别名
RAB7A;RAB7;Ras-related Protein Rab-7a
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51149
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表达区间
1-207aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA SAESCSC
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RAB7A is a member of the RAS oncogene family, playing a vital role in regulating intracellular trafficking and late endosomal/lysosomal transport. It is primarily involved in the maturation of endosomes and the delivery of cargo to lysosomes, a process essential for cellular homeostasis. Dysregulation of RAB7A has been implicated in various diseases, including neurodegeneration, cancer, and感染, highlighting its significance in both physiological and pathological contexts. The study of RAB7A recombinant protein is crucial for understanding its functional mechanisms and interactions within cellular pathways. Researchers are focusing on characterizing this protein to elucidate its role in endosomal dynamics and its implications in diseases. Techniques such as protein purification and functional assays allow for the exploration of RAB7A's interactions with other cellular proteins and its effect on endosomal and lysosomal function. Additionally, given its involvement in disease processes, RAB7A represents a potential therapeutic target, making the understanding of its structure and function increasingly important. Hence, the investigation of RAB7A recombinant protein serves not only to advance basic biological knowledge but also to pave the way for developing effective therapeutic strategies that could mitigate the impacts of diseases associated with RAB7A dysfunction.
