关键信息
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基因名
PTGR1
- 应用
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别名
PTGR2;ZADH1;Prostaglandin reductase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14914
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表达区间
1-329aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSEFMVRTK TWTLKKHFVG YPTNSDFELK TAELPPLKNG EVLLEALFLT VDPYMRVAAK RLKEGDTMMG QQVAKVVESK NVALPKGTIV LASPGWTTHS ISDGKDLEKL LTEWPDTIPL SLALGTVGMP GLTAYFGLLE ICGVKGGETV MVNAAAGAVG SVVGQIAKLK GCKVVGAVGS DEKVAYLQKL GFDVVFNYKT VESLEETLKK ASPDGYDCYF DNVGGEFSNT VIGQMKKFGR IAICGAISTY NRTGPLPPGP PPEIVIYQEL RMEAFVVYRW QGDARQKALK DLLKWVLEGK IQYKEYIIEG FENMPAAFMG MLKGDNLGKT IVKA
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PTGR1, or Prostaglandin Reductase 1, is an essential enzyme involved in the metabolism of prostaglandins, which are lipid compounds that play crucial roles in various physiological processes, including inflammation, pain modulation, and regulation of blood flow. The study of PTGR1 has gained prominence in the context of its potential implications in cancer research, cardiovascular diseases, and other inflammatory conditions. Dysregulation of prostaglandin levels has been linked to tumorigenesis and the progression of several malignancies, making PTGR1 a potential target for therapeutic intervention. Research efforts are focused on understanding the enzyme’s structure-function relationship and its role in prostaglandin metabolism, which could lead to the development of novel drugs that modulate its activity. Furthermore, PTGR1 has been implicated in the resistance of certain cancers to therapy, highlighting its significance in cancer treatment strategies. The production of recombinant PTGR1 enables detailed biochemical studies and the exploration of its enzymatic properties, facilitating drug discovery and the development of new therapeutic approaches. Overall, understanding PTGR1’s function and regulatory mechanisms is crucial for elucidating its role in health and disease, with promising avenues for clinical application in the management of cancer and inflammatory disorders.
