关键信息
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基因名
MRAP2
- 应用
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别名
MRAP2; C6orf117; Melanocortin-2 receptor accessory protein 2; MC2R accessory protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96G30
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表达区间
1-205 aa
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氨基酸序列
MSAQRLISNRTSQQSASNSDYTWEYEYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFM FFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHCYI NEVERLDRAKACHQTTALDSDVQLQEAIRSSGQPEEELNRLMKFDIPNFVNTDQNYFGED DLLISEPPIVLETKPLSQTSHKDLD
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分子量
23.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MRAP2 (melanocortin 2 receptor accessory protein 2) is a recently identified protein that plays a crucial role in the function of melanocortin receptors, particularly the melanocortin 2 receptor (MC2R) involved in adrenal steroidogenesis. The significance of MRAP2 has emerged from studies highlighting its essential role in the transport and proper functioning of MC2R on the cell surface, which directly affects the adrenal glands' ability to produce cortisol in response to adrenocorticotropic hormone (ACTH). Dysfunctional MRAP2 expression or mutations can lead to disorders, such as familial glucocorticoid deficiency (FGD), characterized by impaired adrenal response and altered steroid production. Research into MRAP2 is vital as it enhances our understanding of adrenal physiology and the molecular mechanisms governing hormone signaling pathways. Furthermore, insights gained from MRAP2 studies may pave the way for novel therapeutic strategies for related disorders, emphasizing the need for thorough investigations into its structure, function, and interactions within the melanocortin system. The exploration of MRAP2 not only contributes to endocrinology but also intersects with broader fields such as metabolic regulation and obesity research, making it a significant target for future biomedical studies.
