关键信息
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基因名
TCEA3
- 应用
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别名
TCEA3；TFIISH；Transcription elongation factor A Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75764
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表达区间
1-348aa
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氨基酸序列
MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV AVNGVRKHCS DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE KGLECSDWKP EAGLSPPRKK REDPKTRRDS VDSKSSASSS PKRPSVERSN SSKSKAESPK TPSSPLTPTF ASSMCLLAPC YLTGDSVRDK CVEMLSAALK ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS RISNLKDPRN PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKFC
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分子量
38.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TCEA3, or Transcription Elongation Factor A (SII), has garnered significant attention in recent years due to its crucial role in the regulation of gene expression and RNA processing. As a member of the transcription elongation factor family, TCEA3 is involved in the recruitment of RNA polymerase II and the elongation of nascent RNA transcripts, thereby influencing cellular responses to various stimuli and developmental cues. Dysregulation of TCEA3 has been implicated in several diseases, including cancer, where it may contribute to altered gene expression profiles and tumor progression. The study of TCEA3 is further propelled by its potential as a therapeutic target; understanding its structure and function can lead to the development of novel strategies for manipulating transcriptional regulation in pathological conditions. Recent advancements in recombinant protein technologies have enabled researchers to produce TCEA3 in vitro, facilitating detailed investigations into its biochemical properties and interactions with other cellular components. By elucidating the molecular mechanisms underlying TCEA3's functions, scientists aim to uncover its role in normal physiology and disease etiology, ultimately paving the way for innovative approaches in disease treatment and prevention. This growing body of research highlights the significance of TCEA3 as both a fundamental biological entity and a promising target for therapeutic intervention.
