关键信息
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基因名
MGST3
- 应用
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别名
MGST3; Microsomal glutathione S-transferase 3; Microsomal GST-3; Glutathione peroxidase MGST3; LTC4 synthase MGST3; Microsomal glutathione S-transferase III; Microsomal GST-III
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14880
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表达区间
1-152 aa
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氨基酸序列
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
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分子量
42.46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MGST3, or microsomal glutathione S-transferase 3, is a crucial enzyme that plays a significant role in cellular detoxification processes by catalyzing the conjugation of glutathione to various electrophilic compounds, thereby enhancing their solubility and facilitating their elimination from the body. The interest in MGST3 arises from its involvement in the metabolism of a wide range of substances, including drugs and environmental toxins, making it a pivotal protein in pharmacology and toxicology. Research has indicated that MGST3 is implicated in protecting cells from oxidative stress and may have therapeutic implications in diseases linked to oxidative damage, such as neurodegenerative disorders and cancer. Furthermore, understanding the structural and functional characteristics of MGST3 can provide insights into its enzymatic mechanisms and interactions with substrates. The recombinant expression of MGST3 allows for in-depth biochemical studies and potential applications in drug development, as it aids in the assessment of how various compounds are metabolized and cleared. As the prevalence of drug-resistant diseases rises, the role of MGST3 in drug metabolism becomes increasingly relevant, opening up avenues for personalized medicine that considers individual variations in MGST3 activity. Overall, the study of MGST3 as a recombinant protein not only sheds light on its fundamental biological functions but also holds promise for advancements in therapeutic strategies aimed at mitigating the effects of toxic exposures and optimizing pharmacological interventions.
