关键信息
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基因名
MCSP
- 应用
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别名
HSMCSGEN1 ; MCS ; MCSP ; MCSP_HUMAN; Mitochondrial capsule selenoprotein; SMCP; Sperm mitochondria associated cysteine rich protein; Sperm mitochondrial-associated cysteine-rich protein
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49901
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表达区间
1-116aa
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氨基酸序列
MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK
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分子量
39.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The study of MCSP (Melanoma Cell Surface Protein), also known as gp75 or MART-1, has gained significant attention in the field of cancer immunology and targeted therapy, particularly concerning melanoma. MCSP is a transmembrane glycoprotein primarily expressed in melanoma cells and some other melanocyte-related tissues. Its unique expression pattern makes it a promising target for immunotherapeutic approaches, such as monoclonal antibody development and T-cell receptor-based therapies. Research has shown that MCSP plays a crucial role in tumor cell proliferation, survival, and metastatic behavior, thus contributing to melanoma's aggressive characteristics. The protein's capacity to elicit a robust immune response presents opportunities for novel therapeutic strategies aimed at enhancing anti-tumor immunity. Additionally, understanding the molecular mechanisms governing MCSP's function and its interaction with the immune system could pave the way for innovative treatment modalities. Recent advances in recombinant protein technology enable the production and modification of MCSP, allowing for comprehensive studies on its structure-function relationships and potential applications in diagnostic and therapeutic contexts. As the burden of melanoma continues to rise globally, ongoing research into MCSP holds promise for improving patient outcomes through more effective and targeted intervention strategies.
