关键信息
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基因名
MATN1
- 应用
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别名
MATN1；CMP；CRTM；Cartilage matrix Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21941
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表达区间
23-496aa
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氨基酸序列
SPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV
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分子量
57.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MATN1, or Matrilin-1, is a non-collagenous extracellular matrix protein that plays a critical role in the structural integrity and function of various connective tissues. It is predominantly expressed in cartilage, tendons, and ligaments, where it interacts with other matrix components, facilitating the assembly of extracellular matrix networks. Research has shown that MATN1 is involved in cellular processes such as proliferation, migration, and differentiation, making it a significant factor in tissue development and repair. Abnormal expression of MATN1 has been implicated in several pathologies, including osteoarthritis, where it may contribute to cartilage degradation and altered biomechanical properties. The study of MATN1 recombinant proteins has gained attention as a means to understand its functional roles and interactions within the extracellular matrix, which could have implications for developing therapeutic strategies for connective tissue disorders. Recombinant MATN1 proteins are being used in various experimental models to elucidate their biological effects and potential as biomarkers or therapeutic agents. This focus on MATN1 reaffirms the importance of extracellular matrix components in health and disease, highlighting the need for continued research in elucidating the molecular mechanisms governing connective tissue homeostasis and pathological conditions affecting these crucial structures.
