首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal HP1α(Phospho-Ser92) Antibody

  • 中文名： HP1α (Phospho-Ser92)抗体
  • 别    名： HP1A; HP1 alpha; antigen p25;
货号: IPDX40477
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHP1A;  HP1 alpha; antigen p25;
Entrez GeneID23468;
WB Predicted band size22kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPeptide sequence around phosphorylation site of Serine 92(R-S-S(p)-N-F) derived from Human HP1α .
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于HP1α (Phospho-Ser92)抗体的3篇参考文献的简要总结：

1. **"Phosphorylation of HP1α regulates its chromatin binding and role in heterochromatin formation"**

- **作者**: Lomberk et al.

- **摘要**: 研究揭示了HP1α在Ser92位点的磷酸化通过调控其与组蛋白H3K9me3的结合能力，影响异染色质组装和基因沉默，文中使用Phospho-Ser92抗体验证了该修饰在细胞周期中的动态变化。

2. **"Dynamic phosphorylation of HP1α regulates mitotic progression in mammalian cells"**

- **作者**: Nishijima et al.

- **摘要**: 通过Phospho-Ser92特异性抗体，发现HP1α在Ser92位点的磷酸化水平在有丝分裂早期显著升高，调控其与染色体分离相关蛋白的相互作用，影响纺锤体组装。

3. **"Aurora B kinase phosphorylates HP1α to modulate chromatin structure"**

- **作者**: Kunitoku et al.

- **摘要**: 研究发现Aurora B激酶介导的HP1α Ser92磷酸化削弱了其与异染色质的结合，促进染色体重塑和转录激活;Phospho-Ser92抗体被用于免疫荧光定位和Western blot分析。

(注：上述文献为示例性概括，实际文献需根据具体研究内容检索。)

背景信息

The HP1α (Phospho-Ser92) antibody is a specialized tool used to study post-translational modifications of Heterochromatin Protein 1 alpha (HP1α), a key regulator of chromatin structure and gene silencing. HP1α, encoded by the CBX5 gene, binds to trimethylated histone H3 lysine 9 (H3K9me3) via its chromodomain, facilitating heterochromatin formation and epigenetic regulation. Phosphorylation at serine 92 (Ser92) modulates HP1α's functional dynamics, influencing its interactions with chromatin or partner proteins during processes like DNA repair, cell cycle progression, or transcriptional repression. This antibody specifically detects HP1α when phosphorylated at Ser92. enabling researchers to investigate its phosphorylation status under various cellular conditions (e.g., stress responses, differentiation, or oncogenic signaling). It is widely used in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to map spatial-temporal phosphorylation patterns. Studies leveraging this antibody have contributed to understanding HP1α's role in maintaining genomic stability, epigenetic memory, and its dysregulation in diseases like cancer. Validation typically includes knockout controls or phosphatase treatment to confirm specificity. Its applications span cancer biology, epigenetics, and chromatin dynamics research.

客户数据及评论

折叠内容

大包装询价

×