Cat: PA2000-167DB

Recombinant Human CD23 Protein,His

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关键信息

  • 基因名

    CD23

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CD23;CD23A;CLEC4J;FCE2;Low affinity immunoglobulin epsilon Fc receptor

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P06734

  • 表达区间

    48-321aa

  • 氨基酸序列

    DTTQSLKQLE ERAARNVSQV SKNLESHHGD QMAQKSQSTQ ISQELEELRA EQQRLKSQDL ELSWNLNGLQ ADLSSFKSQE LNERNEASDL LERLREEVTK LRMELQVSSG FVCNTCPEKW INFQRKCYYF GKGTKQWVHA RYACDDMEGQ LVSIHSPEEQ DFLTKHASHT GSWIGLRNLD LKGEFIWVDG SHVDYSNWAP GEPTSRSQGE DCVMMRGSGR WNDAFCDRKL GAWVCDRLAT CTPPASEGSA ESMGPDSRPD PDGRLPTPSA PLHS

  • 分子量

    33 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

CD23, also known as the low-affinity IgE receptor, is a type II membrane protein that plays a crucial role in regulating IgE production and maintaining immune homeostasis. Discovered on the surface of B cells and activated monocytes, CD23 functions as a receptor for IgE and plays a key role in allergenic responses, as well as in the maturation and activation of B cells. Its involvement in various immune processes makes it a significant target for research, particularly in understanding allergic diseases, asthma, and certain types of cancer. The recombinant CD23 protein has been instrumental in elucidating its biochemical properties and functional mechanisms. Studies have shown that CD23 modulates the immune response through its interactions with IgE, contributing to the differentiation of B cells and the secretion of cytokines. This has led to further exploration of its potential as a therapeutic target, particularly in conditions characterized by dysregulated IgE responses. The ability to produce recombinant CD23 has facilitated investigations into its structure-function relationships and the development of novel immunomodulatory therapies. Understanding the role of CD23 at the molecular level may provide insights into innovative treatments for allergic diseases, thereby offering new avenues for improving patient care and outcomes. The ongoing research on CD23 and its recombinant forms is crucial for designing effective interventions targeting IgE-mediated conditions and advancing our knowledge of immune regulation.

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