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Rabbit Polyclonal P38MAPK(Phospho-Thr180) Antibody

  • 中文名： P38 MAPK(Phospho-Thr180)抗体
  • 别    名： MAPK2; MAPKAPK-2; MAPKAPK2
货号: IPDX40234
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMAPK2; MAPKAPK-2; MAPKAPK2
Entrez GeneID1432;
WB Predicted band size43kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPeptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ) derived from Human P38MAPK.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及P38 MAPK (Phospho-Thr180)抗体的参考文献摘要示例：

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1. **文献名称**: *p38 MAPK signaling activation in Alzheimer's disease patients*

**作者**: Smith J, et al.

**摘要**: 本研究利用Phospho-p38 MAPK (Thr180)抗体检测阿尔茨海默病患者脑组织中p38的活化状态，发现磷酸化p38水平与tau蛋白过度磷酸化呈正相关，提示p38异常激活参与神经退行过程。

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2. **文献名称**: *Role of oxidative stress in activating p38 MAPK pathway during myocardial ischemia*

**作者**: Chen L, et al.

**摘要**: 通过Phospho-Thr180特异性抗体证实，心肌缺血模型中活性氧(ROS)通过诱导p38 MAPK的Thr180位点磷酸化激活下游凋亡通路，抑制剂干预可减少心肌细胞损伤。

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3. **文献名称**: *High-throughput screening of p38α inhibitors using phospho-specific antibody-based assays*

**作者**: Kim S, et al.

**摘要**: 开发了一种基于Phospho-p38 (Thr180/Tyr182)抗体的ELISA检测方法，用于高通量筛选p38α激酶抑制剂，验证了多种化合物对LPS诱导的巨噬细胞p38磷酸化的抑制作用。

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(注：以上文献为示例性概括，实际引用需以具体文献为准。建议通过PubMed或Google Scholar以“phospho-p38 MAPK Thr180 antibody”为关键词检索近期论文。)

背景信息

The p38 mitogen-activated protein kinase (MAPK) pathway plays a critical role in cellular responses to stress, inflammation, and apoptosis. Phosphorylation at Thr180 (and Tyr182 in the activation loop) is essential for p38 MAPK activation, enabling its kinase activity toward downstream substrates. The Phospho-Thr180 p38 MAPK antibody specifically detects this phosphorylation event, serving as a key tool to monitor p38 activation status in research. This antibody is widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to study signaling dynamics under conditions such as oxidative stress, cytokine stimulation, or drug treatment. Its specificity for the phosphorylated form allows researchers to distinguish active p38 from its inactive state, aiding in the exploration of pathways involving apoptosis, immune responses, and cell differentiation. Applications extend to disease models, including cancer, neurodegenerative disorders, and inflammatory diseases, where dysregulated p38 signaling is implicated. Validation typically includes testing in knockout models or phosphatase-treated samples to confirm target specificity. By tracking Thr180 phosphorylation, this antibody helps unravel the spatiotemporal regulation of p38 activity, contributing to drug discovery and mechanistic studies of cellular adaptation to extracellular signals.

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