Cat: PA2000-4187

Recombinant Mouse Gzmc Protein,His

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关键信息

  • 基因名

    Gzmc

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Gzmc;

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P08882

  • 表达区间

    21-248aa

  • 氨基酸序列

    IIGGNEISPHSRPYMAYYEFLKVGGKKMFCGGFLVRDKFVLTAAHCKGSSMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYNPDDRSNDIMLLKLVRNAKRTRAVRPLNLPRRNAHVKPGDECYVAGWGKVTPDGEFPKTLHEVKLTVQKDQVCESQFQSSYNRANEICVGDSKIKGASFEEDSGGPLVCKRAAAGIVSYGQTDGSAPQVFTRVLSFVSWIKKTMKHS

  • 分子量

    32.6 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

Gzmc, also known as Granzyme C, is a serine protease predominantly expressed in cytotoxic T lymphocytes and natural killer (NK) cells, and plays a pivotal role in the immune response by facilitating the apoptosis of target cells, particularly virally infected and tumor cells. Research on Gzmc recombinant proteins has gained momentum due to their potential applications in cancer immunotherapy and viral infections. The mechanism by which Gzmc induces apoptosis involves the cleavage of specific substrates within the target cell, leading to programmed cell death. Understanding the structural and functional properties of Gzmc through recombinant protein studies can enhance our comprehension of its enzymatic activity, substrate specificity, and the overall role in the immune system. Furthermore, the ability to produce Gzmc in a recombinant form allows for detailed biochemical analyses and the development of novel therapeutic strategies aimed at augmenting immune responses in various disease contexts. The exploration of Gzmc’s role in the immune landscape is crucial, as it provides insight into potential biomarkers for disease progression and therapeutic targets, particularly in the field of oncology. Consequently, the study of Gzmc recombinant proteins holds significant promise for advancing our understanding of immune mechanisms and developing innovative treatments that harness the body’s natural defense systems.

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