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Rabbit Polyclonal SLC22A4 Antibody

  • 中文名: SLC22A4抗体
  • 别    名: Solute carrier family 22 member 4, Ergothioneine transporter, ET transporter, Organic cation/carnitine transporter 1, SLC22A4, ETT, OCTN1, UT2H
货号: IPDX34844
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSolute carrier family 22 member 4, Ergothioneine transporter, ET transporter, Organic cation/carnitine transporter 1, SLC22A4, ETT, OCTN1, UT2H
Entrez GeneID6583
WB Predicted band size62.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SLC22A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-542 amino acids from the C-terminal region of human SLC22A4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SLC22A4抗体的3篇代表性文献摘要信息:

1. **文献名称**:The role of SLC22A4 in inflammatory bowel disease: Insights from antibody-based expression analysis

**作者**:Tokuhira et al.

**摘要**:通过免疫组化和Western blot分析,发现SLC22A4蛋白在肠道上皮细胞中高表达,其抗体检测显示IBD患者中表达异常,提示其可能参与肠道炎症调节。

2. **文献名称**:Functional characterization of SLC22A4 variants using a monoclonal antibody approach

**作者**:Urban et al.

**摘要**:开发针对SLC22A4的单克隆抗体,验证其特异性后用于细胞膜定位研究,发现特定SNP(rs1050152)影响蛋白转运功能,与类风湿性关节炎风险相关。

3. **文献名称**:SLC22A4 mediates carnitine transport in human cells: Antibody validation and functional assays

**作者**:Tamai et al.

**摘要**:通过抗体阻断实验证实SLC22A4在肉碱转运中的关键作用,研究显示该抗体可抑制细胞对肉碱的摄取,为代谢疾病机制提供新证据。

*注:以上内容为模拟文献概括,实际引用需查询具体论文数据库(如PubMed)。建议以关键词"SLC22A4 antibody"+"expression/function/disease"检索近年高被引论文。*

背景信息

The SLC22A4 antibody is a tool used to detect and study the solute carrier family 22 member 4 (SLC22A4), a transmembrane protein involved in transporting organic cations, such as carnitine and certain drugs. SLC22A4. also known as OCTN1. is expressed in various tissues, including the intestines, kidneys, and immune cells. It plays roles in nutrient absorption, drug disposition, and immune regulation. Research has linked SLC22A4 to autoimmune and inflammatory diseases, particularly Crohn’s disease, where a genetic variant (rs1050152) in its coding region may impair function and contribute to pathogenesis. The antibody is essential for techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze protein expression, localization, and interactions in disease models. Studies also explore its potential in cancer, as altered SLC22A4 expression may influence tumor drug sensitivity. Developing SLC22A4 antibodies requires careful validation due to its structural complexity (12 transmembrane domains) and sequence homology with other SLC22 family members. These antibodies aid in unraveling its physiological roles and therapeutic potential, making them valuable in both basic research and clinical investigations.

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