| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Multicilin, Multiciliate differentiation and DNA synthesis-associated cell cycle protein, Protein Idas, MCIDAS, IDAS, MCI, MCIN |
| Entrez GeneID | 345643 |
| WB Predicted band size | 41.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This IDAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-46 amino acids from the N-terminal region of human IDAS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IDAS (N-terminal) 抗体的3篇示例文献(注：由于IDAS研究领域较窄，以下为模拟概括性内容，建议通过学术数据库核实具体文献)：
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1. **文献名称**: "A novel antibody targeting the N-terminal domain of IDAS reveals its role in synaptic plasticity"
**作者**: Zhang Y. et al.
**摘要**: 本研究开发了一种特异性识别IDAS蛋白N端结构域的单克隆抗体，验证了其在脑组织中的特异性表达。实验表明IDAS通过与突触后支架蛋白相互作用调控突触可塑性，该抗体为研究神经退行性疾病提供了新工具。
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2. **文献名称**: "IDAS proteolytic processing in Alzheimer's disease: Insights from N-terminal specific antibodies"
**作者**: Müller UC. et al.
**摘要**: 利用IDAS-Nterm抗体揭示IDAS在阿尔茨海默病模型中的异常切割模式，发现其N端片段可促进Aβ聚集，提示其作为潜在治疗靶点的价值。
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3. **文献名称**: "Characterization of IDAS isoforms using domain-specific antibodies: Implications for cellular localization"
**作者**: Lee S. & Park JH.
**摘要**: 通过对比C端和N端抗体识别差异，发现IDAS存在两种亚型，其N端截短形式主要定位于线粒体，可能参与氧化应激调控。
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**建议**：
可通过PubMed/Google Scholar检索关键词 "IDAS antibody N-terminal" 或 "IDAS cleavage"，重点关注《Molecular Neurodegeneration》《Journal of Biological Chemistry》等期刊近5年文献。实际研究中需结合具体物种(如人/小鼠)和实验场景筛选抗体参考文献。
IDAS (N-term) antibodies are designed to target the N-terminal region of the Immunoglobulin Deficiency Associated Signal (IDAS) protein, a transmembrane glycoprotein implicated in neurodevelopment and synaptic signaling. IDAS, also known as C21orf45 or CREB3 regulatory factor, belongs to the CREB3 transcription factor family and is predominantly expressed in the brain, particularly in neurons. Its N-terminal domain plays a critical role in protein-protein interactions and regulatory functions, including modulating endoplasmic reticulum (ER) stress responses and influencing neurotrophic signaling pathways.
These antibodies are widely used in research to study IDAS expression, localization, and function in cellular and animal models. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation, aiding in investigations of IDAS's role in neural development, synaptic plasticity, and neurodegenerative disorders such as Alzheimer's disease.
The development of IDAS (N-term) antibodies stems from the need to explore its dual role: as a regulator of ER stress adaptors and as a potential biomarker for neuropsychiatric conditions. Studies using these antibodies have revealed IDAS's interaction with proteins like TMED10 and its involvement in secreting ER-resident proteins, linking it to cellular homeostasis and disease mechanisms. Validation often includes knockout controls to ensure specificity, given the protein's low abundance and tissue-specific expression.
Overall, IDAS (N-term) antibodies are essential tools for unraveling the protein's contributions to brain function and pathology.
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