| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Recombining binding protein suppressor of hairless-like protein, Transcription factor RBP-L, RBPJL, RBPL, RBPSUHL |
| Entrez GeneID | 11317 |
| WB Predicted band size | 56.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RBPJL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human RBPJL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RBPJL (N-term)抗体的3篇参考文献的简要总结(注：文献信息为模拟示例，实际文献需通过数据库检索验证)：
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1. **文献名称**: *RBPJL interacts with PTF1 to regulate exocrine pancreatic-specific gene expression*
**作者**: Masui T, et al.
**摘要**: 研究利用RBPJL (N-term)抗体验证其在胰腺组织中的表达，发现RBPJL与PTF1形成复合物，调控外分泌胰腺特异性基因(如胰蛋白酶原)的转录，揭示其在胰腺发育中的关键作用。
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2. **文献名称**: *RBPJL suppresses pancreatic cancer progression by modulating Notch signaling*
**作者**: Huang L, et al.
**摘要**: 通过RBPJL (N-term)抗体的免疫组化分析，发现RBPJL在胰腺癌中表达下调，其缺失通过激活Notch通路促进肿瘤侵袭。研究提示RBPJL可能作为抑癌分子影响临床预后。
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3. **文献名称**: *Dynamic regulation of RBPJL during acinar-to-ductal metaplasia*
**作者**: Krah NM, et al.
**摘要**: 使用RBPJL (N-term)抗体进行免疫荧光定位，发现RBPJL在胰腺腺泡细胞损伤后表达减少，其缺失与腺泡-导管化生(ADM)过程相关，为胰腺癌前病变机制提供新见解。
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建议通过PubMed或Google Scholar以“RBPJL antibody”或“RBPJL N-terminal”为关键词检索最新文献获取准确信息。
The RBPJL (N-term) antibody targets the N-terminal region of RNA-Binding Protein JL (RBPJL), a transcription factor belonging to the PTF1-like subfamily. RBPJL is structurally related to RBPJ, a key mediator of Notch signaling, but functions independently in tissue-specific regulatory pathways. It plays a critical role in maintaining pancreatic acinar cell identity and regulating genes involved in exocrine function. RBPJL forms a complex with transcription factors like PTF1A and E-proteins to activate target genes, particularly in the pancreas.
Antibodies against the N-terminal domain are commonly used to study RBPJL's expression patterns, localization, and interactions in developmental and disease contexts. Research has linked RBPJL dysregulation to pancreatic disorders, including pancreatitis and pancreatic cancer, making this antibody a valuable tool for investigating molecular mechanisms in these conditions. It is widely applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in cell lines and tissue samples.
The antibody’s specificity for the N-terminal region ensures recognition of full-length RBPJL, aiding in distinguishing it from splice variants or degradation products. Its role in both basic research and potential clinical applications underscores its importance in understanding pancreatic biology and pathology.
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