Rabbit Polyclonal PPP1R3G Antibody

The PPP1R3G antibody targets the Protein Phosphatase 1 Regulatory Subunit 3G (PPP1R3G), a member of the PPP1R3 family that directs protein phosphatase 1 (PP1) to specific substrates to regulate dephosphorylation. PPP1R3G is implicated in glycogen metabolism, acting as a regulatory subunit that recruits PP1 to glycogen-associated complexes, thereby modulating glycogen synthesis or breakdown. Structurally, it contains a conserved carbohydrate-binding module (CBM) that facilitates interactions with glycogen or other proteins. While less studied than other PPP1R3 isoforms (e.g., PPP1R3C or PPP1R3D), PPP1R3G is thought to play tissue-specific roles, with expression observed in skeletal muscle, liver, or adipose tissue, depending on species. Antibodies against PPP1R3G are typically developed in rabbits or mice using immunogenic peptides or recombinant protein fragments. These tools enable detection of endogenous PPP1R3G via Western blotting, immunofluorescence, or immunohistochemistry, aiding research into its metabolic functions. Validation often includes knockout controls to confirm specificity, as cross-reactivity with other PPP1R3 family members is a potential concern. Commercial antibodies are available for studying PPP1R3G's role in diabetes, obesity, or glycogen storage disorders, where dysregulated PP1 activity may contribute to pathogenesis.