| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2 |
| Entrez GeneID | 27123 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2. |
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以下是3篇关于DKK2抗体的代表性文献(示例为虚构，实际文献需根据具体数据库检索)：
1. **文献名称**: *DKK2 Antibody Inhibits Wnt Signaling and Suppresses Osteosarcoma Growth*
**作者**: Li X, et al.
**摘要**: 研究开发了一种特异性靶向DKK2的单克隆抗体，通过阻断DKK2与LRP5/6受体的结合抑制经典Wnt信号通路，在体外和体内模型中显著抑制骨肉瘤细胞增殖并促进凋亡。
2. **文献名称**: *DKK2 Neutralizing Antibody Attenuates Fibrosis in Chronic Kidney Disease*
**作者**: Wang Y, et al.
**摘要**: 该文献报道了一种中和性DKK2抗体在慢性肾病模型中的应用，证明其通过调节Wnt/β-catenin通路减少肾间质纤维化，改善肾功能，提示DKK2抗体在纤维化疾病中的治疗潜力。
3. **文献名称**: *Development of a High-Affinity Anti-DKK2 Antibody for Colorectal Cancer Diagnosis*
**作者**: Chen H, et al.
**摘要**: 研究团队开发了一种高亲和力DKK2抗体，用于结直肠癌组织样本的免疫组化检测，证实DKK2在癌组织中高表达且与患者预后相关，为癌症诊断提供了新工具。
如需具体文献，建议在PubMed或Web of Science中以“DKK2 antibody”为关键词检索，并筛选涉及抗体开发、机制研究或临床应用的文章。
DKK2 (Dickkopf-related protein 2) is a secreted glycoprotein belonging to the Dickkopf family, known for its role in modulating Wnt signaling pathways. As a context-dependent regulator, DKK2 typically acts as an antagonist of Wnt/β-catenin signaling by binding to LDL receptor-related proteins 5/6 (LRP5/6), thereby inhibiting their interaction with Wnt ligands. However, in certain cellular environments, DKK2 may also enhance non-canonical Wnt pathways, contributing to diverse biological processes such as embryonic development, bone formation, and tissue homeostasis. Dysregulation of DKK2 has been implicated in various diseases, including cancer, osteoporosis, and fibrosis.
DKK2 antibodies are immunological tools designed to detect, quantify, or neutralize DKK2 protein in experimental and clinical settings. These antibodies are widely utilized in research to investigate DKK2's functional roles, particularly in cancer biology, where DKK2 exhibits dual oncogenic or tumor-suppressive effects depending on tumor type and microenvironment. For instance, elevated DKK2 expression correlates with poor prognosis in colorectal and gastric cancers, while it may suppress tumorigenesis in hepatocellular carcinoma.
Therapeutic applications of DKK2 antibodies are under exploration, especially in cancers and bone-related disorders. Neutralizing DKK2 antibodies may restore Wnt/β-catenin signaling in osteolytic diseases or block protumorigenic signaling in specific malignancies. Challenges remain in understanding context-dependent DKK2 behavior, necessitating rigorous validation of antibody specificity and functional assays. Current studies also focus on optimizing antibody formats (monoclonal, polyclonal, or engineered variants) for diagnostic and therapeutic precision.
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