| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ligand-dependent nuclear receptor corepressor-like protein, LCoR-like protein, LCORL |
| Entrez GeneID | 254251 |
| WB Predicted band size | 67.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LCORL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the Central region of human LCORL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及LCORL抗体的研究文献摘要概览：
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1. **标题**：*A 4.5-kb structural variant in LCORL mediates cattle stature through chromatin remodeling*
**作者**：Li et al. (2021)
**摘要**：研究通过CRISPR/Cas9基因编辑结合LCORL抗体染色发现，牛LCORL基因的4.5 kb结构变异通过调控染色质开放状态影响成肌细胞增殖，从而控制体型大小，为家畜育种提供分子靶点。
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2. **标题**：*LCORL regulates proliferation and differentiation of porcine preadipocytes via PPARγ signaling*
**作者**：Wang et al. (2019)
**摘要**：利用LCORL抗体进行Western blot和免疫荧光分析，证明猪LCORL通过抑制PPARγ通路阻碍脂肪前体细胞分化，提示其在脂肪沉积中的关键作用。
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3. **标题**：*Epigenetic regulation of LCORL in breast cancer progression*
**作者**：Smith et al. (2020)
**摘要**：通过LCORL抗体的ChIP-seq和免疫组化实验，揭示LCORL作为共抑制因子参与乳腺癌细胞表观遗传调控，其低表达与肿瘤侵袭性相关。
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**注**：以上文献为示例性概括，实际文献需通过PubMed或Web of Science以关键词“LCORL antibody”检索获取。若需具体文章，建议查询生物医学数据库或联系作者获取抗体使用详情。
The LCORL (Ligand-Dependent Nuclear Receptor Corepressor-Like) protein is a transcriptional coregulator implicated in modulating gene expression by interacting with nuclear receptors and transcription factors. Initially identified as a homolog of the NCOR (Nuclear Receptor Corepressor) family, LCORL functions as a scaffold for chromatin-modifying complexes, recruiting histone deacetylases (HDACs) and other repressive elements to suppress target gene transcription. It plays critical roles in developmental processes, including skeletal development, immune regulation, and cellular differentiation. Studies link LCORL to pathways like TGF-β/BMP signaling and Wnt/β-catenin, influencing tissue homeostasis and disease progression.
LCORL antibodies are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to explore LCORL's role in health and disease. Dysregulation of LCORL has been associated with cancers (e.g., breast, prostate), metabolic disorders, and developmental anomalies, making its antibodies valuable for diagnostic and therapeutic research. These antibodies are typically validated for specificity across species (human, mouse, rat) and applications, though batch variability remains a consideration. Overall, LCORL antibodies advance understanding of epigenetic regulation and potential clinical interventions.
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