Rabbit Polyclonal ASB2(N-term) Antibody

The ASB2 (N-term) antibody targets the N-terminal region of the Ankyrin repeat and SOCS box protein 2 (ASB2), a member of the ASB family characterized by ankyrin repeat domains and a C-terminal SOCS box. ASB2 functions as a substrate-recognition component in E3 ubiquitin ligase complexes, facilitating protein ubiquitination and degradation via the ubiquitin-proteasome pathway. It plays roles in cellular processes such as signal transduction, differentiation, and apoptosis, with emerging links to cancer progression, particularly in leukemia and solid tumors. Studies suggest ASB2 may regulate cell migration, metastasis, and proteolytic degradation of specific targets (e.g., vinculin in acute promyelocytic leukemia). The ASB2 (N-term) antibody is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study endogenous ASB2 expression, localization, and interactions. Its specificity for the N-terminal region allows detection of full-length ASB2 isoforms, aiding research into its physiological and pathological mechanisms. Validation typically includes knockout controls to confirm minimal cross-reactivity, ensuring reliability in experimental models. This antibody is a key tool for exploring ASB2's role in cellular homeostasis and disease contexts.