| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 4D11, OR4D11, OR4D11P |
| Entrez GeneID | 219986 |
| WB Predicted band size | 35.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR4D11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the C-terminal region of human OR4D11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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由于OR4D11是一个较为专研的嗅觉受体，针对其抗体的直接研究在公开文献中较为有限。以下是基于相关领域研究的推测性示例，实际文献可能需要通过专业数据库进一步检索：
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1. **标题**: "Antibody production and characterization for olfactory receptor OR4D11 in human tissues"
**作者**: Smith A, et al.
**摘要**: 描述了针对人类OR4D11受体多克隆抗体的开发，验证了其在嗅觉上皮和睾丸组织中的特异性结合，用于免疫组化定位。
2. **标题**: "Expression profiling of olfactory receptors in prostate cancer using immunohistochemistry"
**作者**: Lee C, et al.
**摘要**: 利用OR4D11抗体分析前列腺癌组织中嗅觉受体的异常表达，发现其与肿瘤分级的相关性，提示潜在诊断价值。
3. **标题**: "GPCR-specific antibody library for high-throughput screening"
**作者**: Garcia R, et al.
**摘要**: 开发了一个包含OR4D11抗体的GPCR抗体库，验证了其在流式细胞术和Western blot中的应用，强调跨膜蛋白的检测挑战。
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**注意**：上述文献为示例性质，实际研究中OR4D11抗体的直接文献可能较少。建议通过 **PubMed** 或 **Google Scholar** 使用关键词 "OR4D11 antibody" 或 "olfactory receptor antibody" 获取最新研究。
The OR4D11 antibody is a specialized tool used to detect and study the olfactory receptor family 4 subfamily D member 11 (OR4D11), a protein encoded by the OR4D11 gene. As part of the G protein-coupled receptor (GPCR) superfamily, OR4D11 is primarily expressed in olfactory sensory neurons, where it plays a role in detecting odorant molecules and mediating signal transduction. Though its specific ligand remains uncharacterized, OR4D11 is hypothesized to contribute to the recognition of distinct chemical cues, influencing olfactory perception.
Research involving the OR4D11 antibody focuses on elucidating its expression patterns, localization, and functional roles in both physiological and pathological contexts. While traditionally associated with olfaction, recent studies suggest ectopic expression of OR4D11 in non-olfactory tissues, implying potential roles in cellular processes beyond sensory detection. For example, some investigations explore its possible involvement in cancer progression or metabolic regulation, though findings remain preliminary.
The antibody is commonly utilized in techniques like immunohistochemistry, Western blotting, and flow cytometry to validate OR4D11 presence in experimental models. Its development and validation often involve recombinant protein immunogens or peptide sequences to ensure specificity. Challenges include addressing low endogenous expression levels and cross-reactivity with structurally similar receptors. Overall, the OR4D11 antibody serves as a critical reagent for advancing our understanding of olfactory receptor biology and its broader implications in health and disease.
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