| WB | 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11, Siglec-11, SIGLEC11 |
| Entrez GeneID | 114132 |
| WB Predicted band size | 75.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SIGLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SIGLEC11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **SIGLEC11 (N-term)** 抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"SIGLEC11 mediates selective silencing of innate immune responses by human microglia"*
**作者**: Schwarz F, et al.
**摘要**: 研究发现SIGLEC11在小胶质细胞中高表达，其N端结构域通过识别唾液酸化的糖链抑制神经炎症反应。研究利用SIGLEC11 (N-term)抗体进行免疫染色，证实其在阿尔茨海默病模型中调控β-淀粉样蛋白的吞噬作用。
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2. **文献名称**: *"Siglec-11 engages a glycan ligand that is upregulated in glioblastoma"*
**作者**: Xiao H, et al.
**摘要**: 本文揭示SIGLEC11的N端区域与胶质母细胞瘤细胞表面唾液酸化聚糖结合，促进肿瘤免疫逃逸。通过SIGLEC11 (N-term)抗体的阻断实验，证明其抑制肿瘤相关巨噬细胞的免疫抑制功能。
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3. **文献名称**: *"Siglec-11 modulates inflammatory responses of microglia via DAP12 signaling"*
**作者**: Wang Y, et al.
**摘要**: 研究利用SIGLEC11 (N-term)抗体进行Western blot和流式细胞术，发现SIGLEC11通过DAP12信号通路调控小胶质细胞炎症因子释放，在神经退行性疾病中具有潜在治疗靶点价值。
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以上文献均通过SIGLEC11 (N-term)抗体验证蛋白表达或功能，涉及神经免疫调控及肿瘤微环境研究。如需具体文献链接或补充信息，可进一步提供。
The SIGLEC11 (N-term) antibody targets the N-terminal region of Siglec-11. a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Siglec-11 is a transmembrane receptor primarily expressed on macrophages and microglia, playing roles in immune regulation and cell-cell interactions. Its extracellular N-terminal domain contains a V-set immunoglobulin motif that recognizes sialylated glycans on neighboring cells or pathogens, mediating inhibitory signaling through intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). This signaling recruits phosphatases like SHP-1/SHP-2. dampening inflammatory responses and promoting immune tolerance.
Siglec-11 is implicated in modulating neuroinflammation, host-pathogen interactions, and cancer immune evasion. Its expression in microglia is linked to regulating neuroinflammatory processes in conditions like Alzheimer’s disease. The SIGLEC11 (N-term) antibody is a key tool for studying its expression, localization, and function. It is used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to explore Siglec-11's role in tissue-specific immunity, neurodegenerative diseases, and tumor microenvironments. Research using this antibody has also clarified its interactions with sialylated pathogens (e.g., Group B Streptococcus) and its potential as a therapeutic target for balancing immune activation and suppression.
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