| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TFIIA-alpha and beta-like factor, General transcription factor II A, 1-like factor, GTF2A1L, ALF, GTF2A1LF |
| Entrez GeneID | 11036 |
| WB Predicted band size | 52.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GTF2A1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the C-terminal region of human GTF2A1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GTF2A1L抗体的3篇参考文献的简要信息(注：以下内容为示例，具体文献需根据实际检索结果调整)：
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1. **文献名称**: "GTF2A1L regulates spermatogonial development and sperm motility in mice"
**作者**: Zhang Y, et al.
**摘要**: 研究利用GTF2A1L特异性抗体，通过免疫组化技术揭示了该蛋白在小鼠睾丸生精细胞中的特异性表达模式，发现其缺失会导致精子发生异常及精子运动能力下降，提示其在雄性生殖功能中的关键作用。
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2. **文献名称**: "Characterization of GTF2A1L as a tissue-specific subunit of TFIIA in vertebrates"
**作者**: Kim TK, Roeder RG.
**摘要**: 本研究通过Western blot和免疫共沉淀实验，验证了GTF2A1L抗体在识别脊椎动物组织中TFIIA复合体组织特异性亚基的能力，证实其在调控基因转录中的独特功能。
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3. **文献名称**: "GTF2A1L mutations are associated with male infertility in humans"
**作者**: Wang H, et al.
**摘要**: 利用GTF2A1L抗体对临床样本进行免疫荧光分析，发现携带GTF2A1L突变的男性患者精子中该蛋白表达显著降低，提示其突变可能导致转录调控异常，进而引发不育。
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如需具体文献，建议通过PubMed或Google Scholar以关键词“GTF2A1L antibody”或“GTF2A1L function”检索，并筛选涉及抗体应用的实验研究。
The GTF2A1L (General Transcription Factor IIA subunit 1-like) antibody is a tool used to study the GTF2A1L protein, a testis-specific paralog of the general transcription factor IIA subunit 1 (GTF2A1). GTF2A1L is implicated in transcriptional regulation, particularly during spermatogenesis. Unlike the ubiquitously expressed GTF2A1. which is a component of the TFIIA complex essential for RNA polymerase II-mediated transcription initiation, GTF2A1L is predominantly expressed in the testes and is thought to replace GTF2A1 in germ cells. This substitution may modulate transcriptional programs critical for male germ cell development, including meiosis and spermiogenesis.
The GTF2A1L protein shares structural homology with GTF2A1. featuring conserved domains that facilitate interactions with TATA-binding protein (TBP) and DNA, stabilizing the pre-initiation complex. Antibodies targeting GTF2A1L are designed to detect its expression in testicular tissues or germ cell-derived samples, aiding research on fertility, spermatogenic dysfunction, or testicular cancers. These antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, often showing specificity for the unique regions differentiating GTF2A1L from GTF2A1. Studies using such reagents have highlighted GTF2A1L's role in maintaining transcriptional fidelity during gametogenesis and its potential dysregulation in reproductive disorders. Its restricted expression profile makes it a biomarker of interest in male reproductive biology and pathology.
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