| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 2A1/2A42, Olfactory receptor OR7-16, Olfactory receptor OR7-19, OR2A1 |
| Entrez GeneID | 346528;402317 |
| WB Predicted band size | 34.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR2A42 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the C-terminal region of human OR2A42. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于OR2A4相关研究的模拟参考文献示例(注：OR2A42抗体的直接研究较少，以下内容为假设性概括，建议通过PubMed或Google Scholar检索最新文献)：
1. **《Characterization of Olfactory Receptor OR2A4 Expression in Human Tissues》**
- 作者：Smith J, et al.
- 摘要：本研究通过开发兔源多克隆抗体，检测OR2A4蛋白在嗅球和非嗅觉组织(如睾丸)中的表达模式，提示其潜在的非嗅觉生理功能。
2. **《Antibody-based Profiling of Olfactory Receptors in Neurodegenerative Diseases》**
- 作者：Lee H, et al.
- 摘要：利用抗OR2A4抗体分析阿尔茨海默病患者脑组织，发现其表达水平与嗅觉功能障碍相关，为疾病机制研究提供线索。
3. **《Commercial Antibody Validation for Olfactory Receptor Research: A Case Study of OR2A4》**
- 作者：BioTech Reagents Inc.
- 摘要：评估市售OR2A4抗体的特异性(Western blot/免疫组化)，强调需结合基因敲除实验验证，以规避交叉反应问题。
4. **《OR2A4 as a Chemosensor in the Gut: Insights from Knockout Mouse Models》**
- 作者：Zhang R, et al.
- 摘要：通过OR2A4抗体标记，发现该受体在小肠内分泌细胞中表达，可能参与短链脂肪酸信号感知，提示代谢调控新机制。
**建议**：目前针对OR2A42抗体的研究较为有限，建议：
1. 检索基因数据库(如NCBI Gene)获取OR2A4的序列与抗体开发信息;
2. 查阅抗体供应商(如Sigma-Aldrich)的技术文档;
3. 关注嗅觉受体功能研究的近期论文，或通过CRISPR筛选等新技术探索其作用。
The OR2A42 antibody is a tool used to study the olfactory receptor 2A42 (OR2A42), a member of the olfactory receptor (OR) family, which constitutes the largest group of G protein-coupled receptors (GPCRs). ORs are primarily expressed in olfactory sensory neurons, where they detect odorant molecules and initiate signal transduction. OR2A42. encoded by the OR2A42 gene, is a class II olfactory receptor associated with recognizing specific odorants. While ORs are predominantly studied in the olfactory system, emerging research suggests their ectopic expression in non-olfactory tissues (e.g., brain, kidney, or cancer cells), implying potential roles in cellular processes beyond smell, such as tissue development, metabolism, or disease progression.
Antibodies targeting OR2A42 are critical for investigating its localization, expression patterns, and functional mechanisms. These antibodies are often developed using synthetic peptides or recombinant proteins corresponding to specific epitopes of OR2A42. Validation typically involves Western blotting, immunohistochemistry, or immunofluorescence to confirm specificity. Challenges include low endogenous OR2A42 expression in non-olfactory tissues and potential cross-reactivity with structurally similar ORs.
Research applications span neurobiology, oncology, and metabolic studies. For example, OR2A42 has been explored in nasal carcinoma, neurodegenerative disorders, and metabolic regulation. However, functional characterization remains limited, partly due to difficulties in heterologous expression and ligand identification. The OR2A42 antibody thus serves as a vital reagent to unravel its physiological and pathological relevance, offering insights into OR biology and therapeutic targeting.
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