Rabbit Polyclonal MAP3K15(N-term) Antibody

The MAP3K15 (N-term) antibody is designed to target the N-terminal region of mitogen-activated protein kinase kinase kinase 15 (MAP3K15), a serine/threonine kinase within the MAPK signaling pathway. MAP3K15. also known as TAK1-binding protein 3 (TAB3)-associated kinase, plays a role in regulating cellular responses to stress, inflammation, and apoptosis by activating downstream MAPK cascades. The N-terminal domain is critical for protein-protein interactions and kinase activity modulation. Researchers use this antibody primarily in immunoblotting (Western blot), immunohistochemistry (IHC), and immunofluorescence (IF) to study MAP3K15 expression, localization, and function in various tissues and disease models. It is particularly relevant in studies exploring MAPK pathway dysregulation linked to cancers, neurodegenerative disorders, and metabolic diseases like diabetes. Validated for specificity in human and rodent samples, the antibody helps identify full-length MAP3K15 or its cleavage products, aiding in understanding its role in signaling networks. Its development and optimization often involve peptide immunogen-based approaches to ensure target recognition fidelity. Current research focuses on MAP3K15's potential as a therapeutic target, given its involvement in stress-induced apoptosis and inflammatory signaling.