| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sorting nexin-13, RGS domain- and PHOX domain-containing protein, RGS-PX1, SNX13, KIAA0713 |
| Entrez GeneID | 23161 |
| WB Predicted band size | 112.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SNX13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-807 amino acids from the C-terminal region of human SNX13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SNX13抗体的文献示例(注：内容为模拟示例，建议通过学术数据库核实最新研究)：
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1. **文献名称**: *SNX13 regulates cholesterol metabolism through endosomal transport*
**作者**: Lee, J. et al.
**摘要**: 研究揭示了SNX13通过调控低密度脂蛋白受体(LDLR)的内体分选影响胆固醇代谢，利用SNX13抗体进行免疫荧光和Western blot验证其在内体定位中的关键作用。
2. **文献名称**: *Sorting nexin 13 interacts with Alzheimer's disease-related proteins*
**作者**: Smith, R. et al.
**摘要**: 通过SNX13抗体共免疫沉淀实验，发现SNX13与淀粉样前体蛋白(APP)存在相互作用，提示其在神经退行性疾病中可能参与蛋白运输异常机制。
3. **文献名称**: *SNX13 deficiency impairs autophagy in cancer cells*
**作者**: Chen, Y. et al.
**摘要**: 研究使用SNX13抗体敲低细胞模型，证明SNX13通过调控自噬体形成影响肿瘤细胞存活，其缺失导致自噬相关蛋白LC3-II积累受阻。
4. **文献名称**: *Structural insights into SNX13 BAR domain assembly*
**作者**: Tanaka, K. et al.
**摘要**: 利用SNX13抗体的免疫电镜技术解析了其BAR域介导的膜变形功能，揭示了SNX13在膜重塑中的分子机制。
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建议通过PubMed或Google Scholar检索关键词“SNX13 antibody”或“Sorting Nexin 13”获取最新文献，并注意选择抗体验证数据完整的研究(如KO验证、应用场景明确的论文)。
SNX13 (Sorting Nexin 13) is a member of the sorting nexin family, a group of proteins characterized by their phosphoinositide-binding Phox homology (PX) domains. These proteins play critical roles in membrane trafficking, endosomal sorting, and cellular signaling. SNX13 is distinct within the family due to its unique structural features, including an N-terminal PX domain and a regulator of G-protein signaling (RGS) domain, which enable interactions with signaling molecules and participation in vesicular transport pathways. It is implicated in regulating cholesterol homeostasis, endosomal-lysosomal trafficking, and receptor recycling, with studies linking it to cellular processes such as autophagy and lipid metabolism.
SNX13 antibodies are immunological tools developed to detect and study the expression, localization, and function of SNX13 in various biological contexts. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore SNX13’s involvement in intracellular trafficking mechanisms or disease pathways. Research has associated SNX13 dysregulation with pathologies such as cancer, neurodegenerative disorders, and metabolic syndromes, underscoring its potential as a therapeutic or diagnostic target. Antibodies targeting SNX13 are typically raised in hosts like rabbits or mice, with specificity validated across human, mouse, and rat homologs. Their application aids in elucidating SNX13’s molecular interactions, post-translational modifications, and role in maintaining cellular homeostasis, contributing to broader insights into membrane dynamics and disease mechanisms.
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