| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1 |
| Entrez GeneID | 1385 |
| WB Predicted band size | 35.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CREB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-132 amino acids from the Central region of human CREB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于CREB1抗体的参考文献摘要示例(虚构内容，仅作格式参考)：
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1. **文献名称**: *CREB1 phosphorylation and memory formation in the hippocampus*
**作者**: Silva AJ, et al.
**摘要**: 本研究利用CREB1特异性抗体(货号：ab123)检测大鼠海马区CREB1蛋白的磷酸化水平，发现其与长期记忆形成显著相关。Western blot和免疫组化结果显示，CREB1在神经元激活后表达上调。
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2. **文献名称**: *CREB1-mediated transcriptional regulation in neuronal survival*
**作者**: Lonze BE, Ginty DD
**摘要**: 通过CREB1抗体(Cell Signaling #9197)进行染色质免疫共沉淀(ChIP)实验，证实CREB1直接结合BDNF基因启动子区，调控神经营养因子依赖的神经元存活通路。
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3. **文献名称**: *Antibody specificity validation for CREB1 isoforms*
**作者**: Mayr B, Montminy M
**摘要**: 本研究系统验证了多种市售CREB1抗体的特异性，发现抗体(如Santa Cruz sc-377154)可区分CREB1与同家族蛋白ATF1.为相关研究提供抗体选择依据。
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4. **文献名称**: *CREB1 in circadian rhythm regulation*
**作者**: Altarejos JY, Montminy M
**摘要**: 采用CREB1敲除小鼠模型及免疫荧光(抗体：Abcam ab32515)，证明CREB1通过调控Per2基因表达参与生物钟分子机制，抗体特异性通过siRNA敲低验证。
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注：以上文献信息为模拟生成，实际引用请查询PubMed或Google Scholar数据库。
CREB1 (cAMP response element-binding protein 1) is a transcription factor that plays a pivotal role in regulating gene expression in response to various cellular signals, including cAMP, calcium, and growth factors. It binds to cAMP response elements (CREs) in promoter regions, modulating transcription of target genes involved in processes like neuronal plasticity, memory formation, cell survival, and metabolism. CREB1 activation typically occurs via phosphorylation at specific residues (e.g., Ser133), which enables interaction with coactivators like CBP/p300.
Antibodies targeting CREB1 are essential tools for studying its expression, localization, post-translational modifications, and interactions in biological systems. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specific antibodies may distinguish between total CREB1. phosphorylated forms, or isoforms (e.g., CREB1α/Δα), aiding research into its activation states.
Dysregulation of CREB1 is linked to neurological disorders, cancer, and metabolic diseases, making its antibodies valuable for mechanistic studies and biomarker analysis. Researchers rely on validated CREB1 antibodies to explore its role in signaling pathways (e.g., cAMP/PKA, MAPK) and disease models, ensuring reproducibility in both basic and translational studies. Proper antibody validation (e.g., knockout controls, peptide blocking) is critical to ensure specificity, given homology with related proteins like CREM and ATF1.
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