WB | 1/1000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Olfactory receptor 7G1, Olfactory receptor 19-15, OR19-15, Olfactory receptor OR19-8, OR7G1, OR7G1P |
Entrez GeneID | 125962 |
WB Predicted band size | 34.8kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | This OR7G1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human OR7G1. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR7G1 (N-term)抗体的参考文献示例(内容为虚构,建议通过学术数据库核实具体文献):
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1. **文献名称**: *"Expression and Localization of Olfactory Receptor OR7G1 in Human Olfactory Epithelium"*
**作者**: Smith A, et al.
**摘要**: 研究利用OR7G1 N端特异性抗体进行免疫组化实验,证实OR7G1蛋白在人类嗅觉上皮特定神经元中的表达,并探讨其与嗅觉信号传导的潜在关联。
2. **文献名称**: *"OR7G1 as a Novel Biomarker in Prostate Cancer: Antibody Validation and Clinical Implications"*
**作者**: Johnson B, et al.
**摘要**: 通过Western blot和免疫荧光技术验证OR7G1 N端抗体的特异性,发现OR7G1在前列腺癌组织中异常高表达,提示其可能作为诊断标志物。
3. **文献名称**: *"Functional Characterization of OR7G1 Using CRISPR-Cas9 and Antibody-Based Approaches"*
**作者**: Lee C, et al.
**摘要**: 结合基因编辑技术和OR7G1 N端抗体,揭示OR7G1在细胞膜定位及其与配体结合后的G蛋白激活机制,为嗅觉受体功能研究提供新方法。
4. **文献名称**: *"Development of a Polyclonal Antibody Targeting the N-Terminal Domain of OR7G1 and Its Application in Neurodegenerative Studies"*
**作者**: Garcia D, et al.
**摘要**: 报道一种针对OR7G1 N端结构域的多克隆抗体的开发与验证,并应用于阿尔茨海默病模型,发现OR7G1表达水平与疾病进展相关。
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**注意**:以上文献为示例,实际研究中请通过 **PubMed**、**Google Scholar** 或抗体供应商(如CiteAb、Thermo Fisher)提供的参考文献列表检索真实数据。
The OR7G1 (N-term) antibody is a specialized immunological tool designed to target the N-terminal region of the olfactory receptor 7G1 (OR7G1), a member of the G protein-coupled receptor (GPCR) superfamily. Olfactory receptors, including OR7G1. are primarily expressed in olfactory sensory neurons, where they play a critical role in detecting odorant molecules and initiating signal transduction. OR7G1 is part of the seven-transmembrane domain receptor family, characterized by its extracellular N-terminus and intracellular C-terminus, which facilitate ligand binding and intracellular signaling, respectively.
This antibody is typically produced in hosts such as rabbits or mice using immunogenic peptides corresponding to the N-terminal sequence of OR7G1. It is widely utilized in research applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study the expression, localization, and functional roles of OR7G1 in various tissues. Validated for specificity through knockout controls or peptide-blocking assays, it aids in exploring OR7G1's involvement in olfactory signaling, cellular communication, or potential non-olfactory functions in non-sensory tissues.
Studies employing this antibody contribute to understanding odor perception mechanisms, receptor-ligand interactions, and possible links between olfactory dysfunction and neurological disorders. Its N-terminal targeting ensures recognition of full-length or truncated receptor variants, making it valuable for both basic and translational research in neuroscience and sensory biology.
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