Mouse Monoclonal RAB20 Antibody

The RAB20 antibody is a crucial tool for studying the RAB20 protein, a member of the Rab GTPase family involved in intracellular membrane trafficking and vesicle transport. RAB20. localized to endosomal and lysosomal compartments, regulates processes like endocytosis, autophagy, and organelle dynamics. It plays roles in cellular homeostasis, nutrient sensing, and immune responses, with emerging links to diseases such as cancer, neurodegenerative disorders, and infections. For instance, RAB20 modulates Mycobacterium tuberculosis survival in host cells by altering phagosome maturation. Researchers use RAB20 antibodies (polyclonal or monoclonal, often from rabbit or mouse hosts) in techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize protein expression, localization, and dynamics. Commercial antibodies are validated for specificity, often targeting epitopes within RAB20's conserved GTP-binding domains. Studies leveraging these antibodies have revealed RAB20's tissue-specific expression patterns and dysregulation in tumors, highlighting its potential as a therapeutic target or biomarker. Proper antibody validation via knockout controls remains critical to avoid off-target artifacts in experimental data.