| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glucagon, Glicentin, Glicentin-related polypeptide, GRPP, Oxyntomodulin, OXM, OXY, Glucagon, Glucagon-like peptide 1, GLP-1, Incretin hormone, Glucagon-like peptide 1(7-37), GLP-1(7-37), Glucagon-like peptide 1(7-36), GLP-1(7-36), Glucagon-like peptide 2, GLP-2, GCG |
| Entrez GeneID | 2641 |
| WB Predicted band size | 20.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Glucagon antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from human Glucagon. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下为3-4条关于 **Glucagon抗体** 的参考文献及其简要摘要：
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1. **文献名称**: *Monoclonal Antibodies Directed Against Pancreatic Glucagon*
**作者**: Tager, H.S., et al.
**摘要**: 该研究描述了一种针对胰高血糖素C末端表位的单克隆抗体的开发，验证了其在放射免疫分析(RIA)中的高特异性，并用于检测血浆和胰岛细胞中的胰高血糖素水平。
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2. **文献名称**: *Glucagon Antibody-Based ELISA for Kinetic Analysis of Hormone Secretion*
**作者**: Wewer Albrechtsen, N.J., et al.
**摘要**: 文章提出了一种基于抗体的酶联免疫吸附试验(ELISA)，用于动态监测胰高血糖素分泌，适用于糖尿病研究中胰岛α细胞功能的评估。
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3. **文献名称**: *Immunoneutralization of Glucagon in Metabolic Studies*
**作者**: Campbell, J.E., & Newgard, C.B.
**摘要**: 通过抗体中和胰高血糖素，研究其在糖代谢和肝脏糖异生中的作用，揭示了胰高血糖素拮抗剂对高血糖症的潜在治疗价值。
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4. **文献名称**: *Glucagon Receptor Antibodies and Their Therapeutic Implications*
**作者**: Gylfe, E., et al.
**摘要**: 综述了靶向胰高血糖素受体的抗体研究进展，探讨其在2型糖尿病和肥胖症治疗中通过阻断胰高血糖素信号通路的可能性。
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以上文献均聚焦于胰高血糖素抗体的开发、应用及治疗潜力，涵盖检测技术、代谢机制和临床转化研究。
Glucagon antibodies are essential tools in biomedical research and clinical diagnostics, primarily used to detect and quantify glucagon, a peptide hormone produced by pancreatic α-cells. Glucagon plays a critical role in glucose homeostasis by stimulating hepatic glycogen breakdown and gluconeogenesis, counterbalancing insulin's effects. Antibodies targeting glucagon enable the visualization, localization, and measurement of this hormone in tissues (e.g., pancreatic islets) and biological fluids.
These antibodies are typically generated in animal hosts (e.g., rabbits, mice) using purified glucagon or synthetic peptide fragments as immunogens. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity. Validation methods include immunohistochemistry (IHC), ELISA, and Western blot to ensure minimal cross-reactivity with structurally related peptides like GLP-1 or glicentin.
Applications span diabetes research, metabolic disorder studies, and tumor characterization (e.g., glucagonomas). Challenges include glucagon's low abundance in circulation and susceptibility to degradation, necessitating optimized sample handling. Reliable glucagon antibodies are critical for advancing understanding of α-cell dysfunction, hyperglycemia mechanisms, and therapeutic development. Commercial availability and rigorous validation have expanded their utility in both research and diagnostic settings.
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