Rabbit Polyclonal MAPK1IP1L Antibody

The MAPK1IP1L (Mitogen-Activated Protein Kinase 1 Interacting Protein 1-Like) antibody is a tool used to study the MAPK1IP1L protein, a less-characterized member of the MAPK signaling pathway. MAPK1IP1L is hypothesized to interact with MAPK1 (ERK2), a key kinase regulating cellular responses to growth factors, stress, and differentiation signals. While its exact function remains unclear, MAPK1IP1L is thought to modulate MAPK1 activity, potentially influencing cell proliferation, apoptosis, or adaptation to metabolic changes. Antibodies targeting MAPK1IP1L are typically developed in rabbits or mice using immunogens derived from conserved regions of the human protein. These antibodies enable detection of endogenous MAPK1IP1L via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Their specificity is validated through knockout controls or siRNA-mediated knockdown. Research involving MAPK1IP1L antibodies has been limited but focuses on its potential roles in cancer, neurodegenerative disorders, and metabolic diseases, where MAPK signaling dysregulation is prominent. Recent studies suggest tissue-specific expression patterns, with higher levels observed in brain, liver, and kidney. Challenges include cross-reactivity with homologous proteins like MAPK1IP1 (its better-studied paralog) and the need for further functional characterization. Commercial availability remains restricted, with most antibodies utilized in academic research settings.