| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ephrin type-A receptor 4, EPH-like kinase 8, EK8, hEK8, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, EPHA4, HEK8, SEK, TYRO1 |
| Entrez GeneID | 2043 |
| WB Predicted band size | 109.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This EphA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-70 amino acids from the N-terminal region of human EphA4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于EphA4 (N-term)抗体的示例参考文献(内容为模拟示例，建议通过学术数据库核实实际文献)：
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1. **"Characterization of EphA4 receptor tyrosine kinase in axonal guidance"**
*Author: Smith J, et al.*
摘要：本研究利用针对EphA4 N端结构域(N-term)的抗体，通过免疫沉淀和Western blot验证了其在神经发育中的作用，证明EphA4通过配体结合调控轴突导向。
2. **"EphA4 antibody targeting the N-terminal domain inhibits cancer cell migration"**
*Author: Lee H, et al.*
摘要：开发了一种特异性识别EphA4 N-term的单克隆抗体，实验显示其可阻断Ephrin配体结合，抑制肿瘤细胞迁移，为癌症治疗提供潜在工具。
3. **"Role of EphA4 in synaptic plasticity: Insights from antibody-based assays"**
*Author: Garcia R, et al.*
摘要：通过EphA4 (N-term)抗体的免疫组织化学分析，揭示了该受体在海马区突触可塑性中的表达模式及其与阿尔茨海默病病理的相关性。
4. **"EphA4 extracellular domain antibody modulates spinal cord injury repair"**
*Author: Wang Y, et al.*
摘要：研究使用EphA4 N-term抗体阻断受体活性，促进脊髓损伤后神经再生，验证了该抗体在神经修复中的治疗潜力。
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**注意**：以上文献信息为示例性质，实际引用请通过PubMed、Google Scholar等平台搜索关键词(如“EphA4 N-term antibody”)获取真实文献并核对作者及摘要内容。
The EphA4 (N-term) antibody is a selective tool targeting the N-terminal extracellular domain of the EphA4 receptor, a member of the Ephrin (Eph) receptor tyrosine kinase family. EphA4 plays critical roles in cell-cell communication, regulating processes like axon guidance, synaptic plasticity, and tissue patterning during development. Its N-terminal domain mediates binding to Ephrin ligands (both A and B classes), initiating bidirectional signaling that influences cell adhesion, migration, and cytoskeletal dynamics. Dysregulation of EphA4 is linked to neurological disorders (e.g., ALS, spinal cord injury) and cancer metastasis.
This antibody is widely used in neuroscience and cancer research to detect EphA4 expression via techniques like Western blot, immunohistochemistry, and immunofluorescence. By recognizing the N-terminal region, it helps study receptor localization, activation states, and interactions in physiological or disease models. Validation often includes testing in EphA4-overexpressing cell lines or knockout controls to ensure specificity. Commercial EphA4 (N-term) antibodies are available from multiple suppliers, with host species (e.g., rabbit, mouse) and conjugate options tailored to experimental needs. Its utility in both basic research and therapeutic target validation underscores its importance in understanding EphA4-mediated signaling pathways.
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